Lectures

Hermaphroditism

by Carlo Raj, MD
(1)

Questions about the lecture
My Notes
  • Required.
Save Cancel
    Learning Material 2
    • PDF
      Slides DifferentialDiagnoses Male ReproductivePathology.pdf
    • PDF
      Download Lecture Overview
    Report mistake
    Transcript
    Our next topic is hermaphroditism. With hermaphroditism, we’ll talk about two major categories here. You go through the flowchart algorithm. You’ll get all your questions right. First, we have ovotesticular disorder. We have 46 XX which is a much greater genotypic pattern than 46 XY. So most of your patients here will be of genotype 46 XX. That’s where your focus should be. Both ovary and testicular tissues are present. We call this ovotestis. The genitalia will be ambiguous. This is hermaphroditism. On the other side, we have disorder of sex development, DSD. This is where we’ll spend a little bit more time because of the actual pathogenesis. The reason we go into this is because now you’re getting to what's known as pseudo-hermaphrodite. So what’s the difference between hermaphroditism, true versus pseudo? A true hermaphrodite will have a penis and will have functioning ovaries. Ovotesticular disorder, very straightforward. Here, 46 XX is then referred to as your disorder sex development. Our next step would be ovaries are present, external genitalia are virilised or ambiguous due to excessive, inappropriate exposure to androgen causing early gestation. We’ll talk about this or we had already when we talked about congenital adrenal hyperplasia or exogenous use in pregnancy. Here you have a patient, a pseudo-hermaphrodite. What does that mean to you? Genotype, 46 XX, a female. Now what happens is the fact that your patient is being exposed to tons of androgen. Would you tell me the most common cause of CAH, congenital adrenal hyperplasia? 21 ?-Hydroxylase deficiency. With that enzyme deficiency, you’re then going to have what? Remember what you’re going to shunt, anti-reticularis, lots of androgen. A young girl will then show you ambiguous genitalia or exogenous use of androgen in pregnancy. On the other side, we have 46 XY type...

    About the Lecture

    The lecture Hermaphroditism by Carlo Raj, MD is from the course Reproductive Hormone Disorders.


    Included Quiz Questions

    1. Normal genitalia
    2. Might be XX
    3. Might be XY
    4. They have a Testis
    5. They have ovaries
    1. 21-hydroxylase deficiency
    2. 11β-hydroxylase deficiency
    3. 17α-hydroxylase deficiency
    4. Lipoid CAH
    5. None of the above
    1. Male Pseudo-Hermaphroditism can be caused by maternal ingestion of androgen during pregnancy.
    2. Female Pseudo-Hermaphroditism can be caused by CAH.
    3. Female Pseudo-Hermaphroditism ---> ovaries
    4. Male Pseudo-Hermaphroditism ---> testis
    5. Pseudo-Hermaphroditism ---> ambiguous genitalia

    Author of lecture Hermaphroditism

     Carlo Raj, MD

    Carlo Raj, MD


    Customer reviews

    (1)
    5,0 of 5 stars
    5 Stars
    5
    4 Stars
    0
    3 Stars
    0
    2 Stars
    0
    1  Star
    0