Well, the bone marrow here is
what you’re looking at.
And so therefore, you’ll begin with what’s
known as your pluripotent stem cell.
And with your
pluripotent stem cell,
you’ll take a look at on the left and you
find giving rise to your lymphocyte origin.
On your left, lymphocyte.
Where am I?
In the bone marrow.
What are you going to begin with?
On the very top, a progenitor or
pluripotent stem, stem, stem cell.
Depending as to what
kind of factors come in,
These stem cells are then going to
differentiate into a lymphoid on your left
or on the right, all
will be myeloid.
The quick one here
will be on the left.
If you’re dealing with ALL, the
youngest age group of leukemias,
these are lymphocytic and might
have to be T-cells and B-cells.
Later on, we’ll talk
Obviously dealing with CLL.
There are only 2 types, T-type and B-type.
Now, I could tell you
that the type that you want to
pay attention to, either B or T,
will have to be a B.
And that’s a good thing.
I'll tell you why.
If unfortunately your patient goes
on to develop leukemia as a child,
you want it to or you’re hoping
that it would be the B type.
You’ll see why.
The T type will kill the child.
B type, prognosis is good.
We’ll talk more later.
On the right,
what kind of influences
are taking place here?
These are your granulocyte.
CFU stands for colony forming unit
and with this, you have your
granulocyte, monocyte and CSF.
So these are stimulating factors.
If you’re giving rise to your granulocytes,
you’re thinking about your --
your thinking about your basophils,
neutrophils and your eosinophils granulocytes.
And in granulocyte, you’re
thinking about your monocytes.
What else are you giving
rise to with the myeloid?
If you take a look at the
far right bottom portion,
the 2 cells that we're giving
rise to on the very right.
If you take a look at that
cell, that’s a nucleated RBC.
So it’s an erythroid progenitor.
They might be thinking about
What is that going
to give rise to?
With the help of erythropoietin.
Coming from the kidney, you’re
going to give rise to your RBC’s.
What’s the one next to it?
That’s your platelet/thrombo.
But what do you call this
when it’s in the bone marrow?
This then gives you
Do you see here
That the myeloid lineage giving rise to
many, many, many different types of cells.
You do want to know about
the interleukins here?
If it’s going to be interleukin-5,
you give rise to eosinophil.
And then on the left here are the neutrophils
and monocytes that I was referring to.