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Slides AdrenalInsufficiencyCongenitalHyperplasia EndocrinePathology.pdf
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00:01 Let’s do glucocorticoid in pharmacology. 00:04 Compared with cortisol, these synthetic derivatives have better oral availability, longer half-life, less mineralocorticoid activity... compared with cortisol. 00:13 We’re talking about synthetic derivatives of cortisol. 00:16 Examples: hydrocortisone, prednisone, prednisolone and betamethasone. 00:22 These drugs you should be extremely familiar with, these are synthetic pharmacologic glucocorticoids. 00:27 Adverse effects, we talked about iatrogenic Cushing’s. 00:30 Why in the world are we talking about Cushing’s here? Only because on the outside, the patient looks like a typical Cushing’s patient; on the inside, what is actually happening? The adrenals are undergoing atrophy. 00:45 Remember secondary adrenal insufficiency. 00:47 The adrenals are atrophic. 00:50 What else is happening when you give glucocorticoid? This is a nice little summary of adverse effects. 00:55 Suppression of skeletal growth in children, decreased wound healing, suppression of immune system, varied central nervous system effects. 01:04 The suppression of ACTH, in fact, once again will cause secondary adrenal insufficiency. 01:09 You will never abruptly stop this patient from taking glucocorticoid-glucocorticoid, never. 01:18 If that occurs and the patient gets into a physiologic stressful situation such as shock, the patient’s going to die of Addisonian crisis.
About the Lecture
The lecture Glucocorticoids in Pharmacology – Adrenal Insufficiency by Carlo Raj, MD is from the course Adrenal Gland Disorders.
Included Quiz Questions
All are true of glucocorticoids EXCEPT which of the following?
- They do not cause Cushing's syndrome
- They have better oral availability than cortisol
- They are synthetic derivatives of cortisol
- They have a longer half-life than cortisol
- They have less mineralocorticoid activity than cortisol
An Addisonian crisis can occur when which of the following happens?
- Chronic glucocorticoid therapy is stopped abruptly
- Synthetic cortisol is given to patients with adrenal insufficiency
- Cushings's syndrome progresses
- Immune system response to an infection
- A patient on glucocorticoid therapy increases the dose
Author of lecture Glucocorticoids in Pharmacology – Adrenal Insufficiency
Carlo Raj, MD
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