Glucagon Basics and Regulation of Glucagon Secretion

by Thad Wilson, PhD

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    00:00 Glucagon.

    00:01 Here we need to talk about where it's produced.

    00:05 Glucagon is produced in the islet cells and specifically the alpha component.

    00:11 We also think about there are few other places in which glucagon like substances are produced.

    00:17 And that is in the GI system.

    00:19 This procudes glucagon like peptide.

    00:22 But the primary glucagon is from the pancreas.

    00:27 Now, we have to think about how long is glucagon in the circulation.

    00:33 About 80% of it is cleared after the first path.

    00:38 And you remember what the first path is, this is as you go through the circulartory system one time, the liver is going to clear about 80%.

    00:48 That means that the half life of glucagon is only 5 to 10 minutes.

    00:54 So it's not going to be around for too long period of time.

    00:58 It's good things to keep in mind as you're talking about where it's produced.

    01:03 How long it's going to stay in circulation.

    01:06 The things that control the secretion of glucagon are decrease in blood glucose.

    01:12 So blood glucose level is low, it's going to be a stimulus to make more glucagon.

    01:20 If there is an increase in amino acid concentration, specially, arginine and lysine, as well as the sympathetic nervous system is engaged.

    01:30 The fight or flight response stimulates glucagon release.

    01:34 We also have stress and excercise that both being potent stimuli for glucagon.

    01:42 A few things inhibit glucagon secretion.

    01:45 Insulin being the primary one.

    01:47 So if insulin levels are high it's going to suppress glucagon release.

    01:53 The last item is the somatostatin is also in the pancreatic islet cells.

    01:58 And there in fact potentially decrease it's secretion right from the islet.

    02:11 Glucose, amino acids, fatty acids, and even secretin and cholecystokinin can also be involved in this process of inhibiting glucagon secretion.

    02:22 These will be associated with increases with a meal.

    About the Lecture

    The lecture Glucagon Basics and Regulation of Glucagon Secretion by Thad Wilson, PhD is from the course Endocrine Physiology.

    Included Quiz Questions

    1. Alpha cells
    2. Beta cells
    3. Gamma cells
    4. Delta cells
    5. Acinar cells
    1. 7.5 minutes
    2. 1.5 minutes
    3. 2.5 minutes
    4. 10.5 minutes
    5. 12.5 minutes

    Author of lecture Glucagon Basics and Regulation of Glucagon Secretion

     Thad Wilson, PhD

    Thad Wilson, PhD

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