Gamma-Delta T-Cells, T-Cell Receptor and Alpha-Beta T-Cells – Cell-Mediated Immunity

by Peter Delves, PhD

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    Let’s just spend a couple of moments to look at gamma-delta (γδ) T-cells, and exactly what they do and what they are. They appear to have a distinct role that is complementary to that of the alpha-beta (αβ) T-cells. They comprise less than five percent of the T-cells. So they’re very much a minority population of T-cells. And they’re present mostly in the gut mucosa, in the skin, in the lungs and in the uterus. And they can directly recognize microbial pathogens, and also damaged or stressed host cells. In other words, our own cells that are damaged due to infection or other types of pathology. To give you just a couple of examples of the recognition that can occur by γδ T-cells. You can have direct recognition of phosphoantigens from Mycobacterium tuberculosis, from Plasmodium malariae without any requirement for antigen processing whatsoever. And there can be direct recognition of the MHC-like non-peptide-binding molecules, MICA and MICB, or of CD1 irrespective of any lipoprotein or glycolipid antigen. So they can recognize structures that are coming from foreign pathogens, but they can also recognize our own molecules that are upregulated in response to stress or other events. Here’s the structure of the T-cell receptor on the surface of a T-lymphocyte. It’s a heterodimer, consists of two chains. And here we can see the αβ T-cell receptor. The γδ T-cell receptor looks almost identical. In both cases, the two chains of the T-cell receptor are linked together by a disulfide bond. There are transmembrane segments associated with both chains of the T-cell receptor. Each chain is folded into two domains; a Variable domain which is stabilized by an intra-chain disulfide bond, and a Constant domain also stabilized by an intra-chain disulfide bond. Looking at exactly how the T-cell receptor interacts with peptide...

    About the Lecture

    The lecture Gamma-Delta T-Cells, T-Cell Receptor and Alpha-Beta T-Cells – Cell-Mediated Immunity by Peter Delves, PhD is from the course Humoral Immunity and Cell-Mediated Immunity. It contains the following chapters:

    • A Closer Look on Gamma-Delta T-Cells
    • Structure of the T-Cell Receptor
    • A Closer Look on Alpha-Beta T-Cells

    Included Quiz Questions

    1. T-bet
    2. STAT6
    3. RORγt
    4. Bcl-6
    5. RUNX3
    1. Bcl-6
    2. Phosphoantigens from M. tuberucolsis
    3. Phosphoantigens from P. malariae
    4. CD1
    5. MICA or MICB
    1. MHC alpha helices, CDR the of the T cell variable regions
    2. MHC beta-globulin, T cell hypervariable regions
    3. MHC beta-globulin, CDR of the T cell variable regions
    4. MHC alpha helices, T cell alpha and beta chain constant regions
    5. MHC alpha helices, CDR of the T cell constant regions
    1. Th1, Th2, and Treg
    2. Th1, Th17, and Treg
    3. Th2, Tfh, and Treg
    4. Th1, Th2, and Tfh
    5. Th2, Th17, and Tfh

    Author of lecture Gamma-Delta T-Cells, T-Cell Receptor and Alpha-Beta T-Cells – Cell-Mediated Immunity

     Peter Delves, PhD

    Peter Delves, PhD

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