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Functional Modes of Cytokines and Cytokine Receptor Signaling – Cell-Mediated Immunity

by Peter Delves, PhD
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    The way in which cytokines function, can be looked at in a variety of ways. First of all, which cells produce cytokines, and which cells respond? Well, sometimes the same cell that produces the cytokine, responds to that cytokine. In other words, the cytokine acts in autocrine way. So we can see here, a lymphocyte that’s producing a cytokine and its also has the receptor for that cytokine. So not only will it produce the cytokine but that single cell itself will respond to that particular cytokine. And that often happens, but perhaps even more commonly is a paracrine function, in other words one particular cell produces a cytokine and a different cell responds to it. But do remember, in order to respond to a cytokine, you need to have a cytokine receptor. We can then look at the way in which cytokines work in a kind of network, because there are lots and lots and lots and lots of different cytokines. And the ultimate response will depend upon the mixture of cytokines that’s present in a particular local environment at any one point in time. So they can act in a cascade way, so here we have an example of a Th1 cell secreting a cytokine that’s going to activate macrophages. So for example, gamma interferon as we’ve already heard, very potent macrophage activator. As a result of that stimulation by gamma interferon, the macrophage releases interleukin-12. And one of the effects of interleukin-12 is to stimulate Th1 cells which in turn go on and secrete more gamma interferon, plus interleukin-2 and tumor necrosis factor beta. So this is a cascade type of system. But there are other ways in which cytokines interact with each other, and other types of activity of cytokines. So let’s have a look at...

    About the Lecture

    The lecture Functional Modes of Cytokines and Cytokine Receptor Signaling – Cell-Mediated Immunity by Peter Delves, PhD is from the course Humoral Immunity and Cell-Mediated Immunity. It contains the following chapters:

    • Functional Modes of Cytokines
    • Cytokine Receptor Signaling

    Included Quiz Questions

    1. IFNγ
    2. IL-5
    3. IL-13
    4. IFNβ
    5. M-CSF
    1. Macrophage activation
    2. T cell proliferation
    3. B cell proliferation
    4. NK cell activation
    5. Enhanced adaptive immune response
    1. The JAK-STAT pathway would not be initiated and the target cell gene transcription would be uneffected
    2. Janus kinase would be up regulated
    3. STAT would be directly inhibited, making it incapable of effecting the target cell gene transcription
    4. Cytokines would not be able to reach the nucleus of the target cell
    5. STAT dimers would proliferate in the cytoplasm of the target cell

    Author of lecture Functional Modes of Cytokines and Cytokine Receptor Signaling – Cell-Mediated Immunity

     Peter Delves, PhD

    Peter Delves, PhD


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