Quick Review: Drug-induced Lupus and Systemic Lupus Erythematosus (SLE)

00:01 Alright, so let's do some review questions.

00:02 I'll ask a question, pause the screen and unpause when you're ready to go over the answer.

00:07 Number one, all of the following are associated with drug-induced lupus except -- So as I said before, the anti-histone antibody is very specific for drug-induced lupus, so that's gonna stay there.

00:24 ANA is also associated with drug-induced lupus.

00:27 The anti-Smith antibody however is specific for SLE.

00:31 You shouldn't see that with drug-induced lupus.

00:34 Finally just to round things out, drug-induced lupus is associated with equal gender predisposition and normal complement levels.

00:41 So the answer is number three.

00:44 Okay, next question. Which medications are classically associated with drug-induced lupus? Well, you remember our med ship delivering goodies, medications, and lupus symptoms? It's methyldopa, etanercept, diltiazem, sulfasalazine, hydralazine, INH, and procainamide.

01:07 You may not be able to remember all seven of those medications but at least if you're thinking whether a medication could causes drug-induced lupus, ask yourself if it starts with anyone of those letters.

01:17 Next stop, which of the following is not part of the diagnostic criteria for lupus? Alright, remember our 4 Skin RASHNIA criteria? That includes the Malar rash, the presence of anemia which is a hematologic manifestation, seizures which is a neurologic manifestation, fever is actually not on the list.

01:44 Constitutional symptoms like fever are not part of the diagnostic criteria cuz they're too non-specific.

01:49 The pericardial effusion in contrast would meet the serositis criteria. So the answer is number four.

01:57 Okay, next stop, how does one treat lupus nephritis? So there's a couple different ways you can answer this question; you could start with an ACE inhibitor, you could add on steroids, and often times you're gonna add on mycophenolate mofetil or cyclophosphamide.

02:16 One last question, which of the following is not typically associated with mixed connective tissue disease? Like many diseases, there are families associated with certain conditions.

02:32 And it's important for you to recognize which diseases run in families.

02:35 So the mixed connective tissue disease family includes lupus, systemic sclerosis, polymyositis, and rheumatoid arthritis along with things like the Raynaud's phenomenon.

02:46 Sarcoidosis alas is not part of the family.

02:50 And with that, we've concluded our discussion of systemic lupus erythematosus.