DNA Replication – DNA, RNA and the Genetic Code

by Kevin Ahern, PhD

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    00:01 Now, DNA replication is a very essential process for cell to undergo because of course the DNA has to be replicated in order for a cell to divide. DNA replication is something that is rather intricate; it begins at a sequence called an origin, that's a specific sequence within a DNA molecule. It requires of course the four deoxyribonucleotides, dATP, dGTP, dCTP and dTTP. It requires a DNA polymerase, and a DNA polymerase has a couple of functions and abilities. One, it can read the strand that it's copying so it knows which nucleotide to put in place opposite the base that is putting in. Second, it's capable of catalyzing the formation of phosphodiester bonds, that backbone that's necessary to make the joints between the individual nucleotides on a strand. The replication process is actually quite intricate and requires quite a few enzymes in order to occur. It does occur at a formation called a replication fork, but this is more than I can go into in the lecture here, so I'll save that for another module.

    About the Lecture

    The lecture DNA Replication – DNA, RNA and the Genetic Code by Kevin Ahern, PhD is from the course Biochemistry: Basics.

    Included Quiz Questions

    1. It requires DNA polymerase.
    2. It always starts in the cell with a primer made of DNA.
    3. It requires a helicase to relieve DNA tension.
    4. The lagging strand is made in one continuous piece.
    5. It requires RNA polymerase.

    Author of lecture DNA Replication – DNA, RNA and the Genetic Code

     Kevin Ahern, PhD

    Kevin Ahern, PhD

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