Diagnosis of Hepatitis B Virus Infection (HBV) and Interpretation of HBV Serology

by Carlo Raj, MD

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    As I've told you, what our focus would be here with Hepatitides of viral type will be diagnosis. Let’s begin. You’ll notice that the symptoms are taking place on the X axis. We have months after infection. I want you to begin approximately two months here. So, approximately 2 to 4 months, the patient is having symptoms. What kind of symptoms this would be? For the most part, jaundice. Okay, jaundice. Remember anything beyond four weeks of hepatitis B, You usually wouldn't find your jaundice. As the gray shaded box is illustrating. Let's continue. What is viral hepatitis? Which transaminases are elevated more so? ALT? I want you to focus on the red line here and see where it has peaked? ALT should be your focus when dealing with Viral Hepatitis. Next, we'll take a look at the others, we have green, which is the green which is the IgG. And we have IgM. At this point, I want you to focus on IgM. You know that IgM is the first immunoglobulin to appear anytime there is infection Immediate, if that helps you-IgM. Eventually, that IgM is replaced by what kind of immunoglobulin? That would be IgG. These things, in terms of switching and such these discussions take place in immunology I’m just giving a quick review here. So that you can quickly give a diagnosis of a patient with hepatitis B. Next. There are different kinds of hepatitis B surface antigen, E antigens, and DNA. And those all play a role in for the most part in descending order. The Hepatitis surface antigen shows up a little bit later. E antigen shows up quite early And the HBV DNA will show up extremely early. You will notice that we have the yellow line. and the gold line which is...

    About the Lecture

    The lecture Diagnosis of Hepatitis B Virus Infection (HBV) and Interpretation of HBV Serology by Carlo Raj, MD is from the course Cirrhosis – Liver Diseases.

    Included Quiz Questions

    1. 2 to 4 months
    2. 0 to 2 months
    3. 4 to 6 months
    4. 1 to 2 years
    5. 2 to 4 years
    1. IgM Anti-HBc
    2. IgG-Anti HBc
    3. Anti HBe
    4. Anti HBs
    5. HBsAg
    1. Anti HBs
    2. Anti HBe
    3. IgM Anti HBc
    4. IgG Anti HBc
    5. HbsAg
    1. Patient had prior infection of Hepatitis B
    2. Patient is having acute infection of Hepatitis B
    3. Patient had prior vaccination for Hepatitis B
    4. Patient is a chronic Hepatitis B carrier
    5. Patient has chronic hepatitis B
    1. Anti Hbs positive
    2. HbsAg, Anti HBc IgM and HbeAg are positive
    3. HBsAg, Anti HBc IgG and Anti HBeAg are positive and HBV DNA is less than 20000 copies
    4. HBsAg, Anti HBc IgG and HBeAg are positive and HBV DNA is more than 20000 copies
    5. Anti HBs and Anti HBc IgG
    1. Defer collection of blood from this donor
    2. Collect the blood and use the blood for transfusion
    3. Ask him to return when his serology shows positive for Anti HBc IgG and Anti HBe
    4. Advice him to consult a gastroenterologist
    5. Advice him to repeat serology testing 6 months later and donate blood

    Author of lecture Diagnosis of Hepatitis B Virus Infection (HBV) and Interpretation of HBV Serology

     Carlo Raj, MD

    Carlo Raj, MD

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