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Dermatomyositis and Polymyositis

by Carlo Raj, MD
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    00:00 Take a look at dermatomyositis or polymyositis.

    00:03 I want you to focus upon dermato- and that to you of course means skin.

    00:08 When this type of autoimmune disease is kicking in, Understand that the skin is going to be the first thing to be affected You've heard of heliotrope rash around the eye, periorbital.

    00:19 You've heard of Graafian lesions, and that's over your knuckles.

    00:22 So those are rashes that the patient might then be describing to you over the knuckles and so forth.

    00:27 And then what do you think is involved? Good, myo- means muscle.

    00:32 So dermatomyositis, autoimmune diseases once again, what's going on here? Could the lung be involved? Very much so.

    00:39 Whenever you think about autoimmune diseases, then who is your gender most likely? Females.

    00:45 also seen with, well, who's to know the antibody antisynthetase antibodies with dermatomyositis.

    00:53 Frequent involvement of the skin, I gave you a couple there, heliotrope and I gave you Graafian lesions in muscles associated with the lung disease, that should clue you in.

    01:03 Now here we go again.

    01:05 If you do not have much fibrosis, think of this as being a continuum Continuum of what? The amount of fibrosis that you're laying down.

    01:13 If it is not much, you then refer to it as being nonspecific interstitial pneumonitis What's that mean? Oh, look I don't find many fibroblast.

    01:22 So once again from histo, make sure that you are clearly, clearly familiar with what a fibroblast looks like.

    01:31 If you have increased deposition of fibrosis, uh oh we have usual interstitial pneumonitis and pathologically or excuse me, clinically we then call this or diagnose this idiopathic pulmonary fibrosis.

    01:44 High association with occult malignancy, and that is unfortunate.


    About the Lecture

    The lecture Dermatomyositis and Polymyositis by Carlo Raj, MD is from the course Restrictive Lung Disease.


    Included Quiz Questions

    1. Anti-synthetase antibodies
    2. Anti-Smith antibodies
    3. Anti-TPO antibodies
    4. Anti-topoisomerase antibodies
    5. Anti-centromere antibodies
    1. Occult malignancy
    2. Bronchiolitis obliterans
    3. Caplan syndrome
    4. Esophageal dysmotility
    5. Pulmonary HTN
    1. CREST syndrome
    2. Systemic scleroderma
    3. Polymyositis
    4. Systemic lupus erythematosis
    5. Rheumatoid arthritis

    Author of lecture Dermatomyositis and Polymyositis

     Carlo Raj, MD

    Carlo Raj, MD


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