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Cross-Presentation – Antigen Processing and Presentation

by Peter Delves, PhD
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    So those are the two classically defined processes of antigen presentation. The presentation of endogenous antigen to CD8+ T-cells using MHC Class I, and the presentation of exogenous antigen to CD4+ T-cells using MHC Class II. But in fact, those pathways are not absolutely set, they’re kind of interconnected in you like. An exogenous antigen can be presented using MHC Class I. An endogenous antigen presented using MHC Class II, as we can see on this particular slide. And this isn’t a rare event. This is happening all the time because often you will want exogenous antigens to be presented to CD8+ T-cells and you’ll want endogenous antigens to be presented to CD4+ helper and regulatory T-cells. So the endogenous and exogenous pathways are not completely separated from each other. Endogenous antigens can enter the Class II pathway and be presented to CD4+ helper and regulatory T-cells. And exogenous antigens can enter the Class I pathway and be presented to CD8+ cytotoxic T-cells. Let’s just look at one example of cross presentation. Here we have a virus infected cell. And antigens are being processed and presented using MHC Class I on this virus infected cell. However, you can have capture of these antigens, either infected cells or viral antigens that are picked up by the antigen presenting cells in the infected individual. So for example a dendritic cell can pick up antigen, and these viral antigens can then enter the cytosol. So they’ve been engulfed by endocytosis or phagocytosis, and normally they would be given to the MHC Class II pathway. But now they’re being put into the MHC Class I pathway because the antigen escapes from the vesicles and enters the cytosol. And then they can go through the normal Class I pathway using that immunoproteasome that we heard...

    About the Lecture

    The lecture Cross-Presentation – Antigen Processing and Presentation by Peter Delves, PhD is from the course Adaptive Immune System.


    Included Quiz Questions

    1. Exogenous antigens are presented by MHC class I.
    2. Endogenous antigens are presented by MHC class I.
    3. Exogenous antigens are presented by MHC class II.
    4. Endogenous antigens are presented to CD 8 positive T-Cells.
    5. The peptide from an MHC class II molecule is transferred into the peptide-binding groove of an MHC class I molecule.
    1. γδ T-cells
    2. NK cells
    3. B1 cells
    4. PRRs
    5. MHC class I

    Author of lecture Cross-Presentation – Antigen Processing and Presentation

     Peter Delves, PhD

    Peter Delves, PhD


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