Cross-bridge Cycling

by Thad Wilson, PhD

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    00:01 So let’s go through the process of cross-bridge cycling.

    00:05 Just to orient you, the actin fiber is going to be listed in small dots, and these are the polymers associated with actin filament.

    00:17 The myosin will be the thick filament and will also include a myosin head, and we’ll only include one, but know there are a plethora of myosin heads that will be contracting continuingly, more like you would think of a ship being rowed by a number of individuals.

    00:35 So let’s start at this process and then walk it around in a circle.

    00:40 We’re starting off here with the myosin head bound to the active site on actin.

    00:46 Here, we have a dephosphorylated ATP or an ADP.

    00:53 What we want to do at this particular point is undergo a power stroke.

    00:59 How this happens is as soon as the myosin head binds to this active site on actin, you’ll get a conformational change of this protein.

    01:10 It then moves actin as the conformational change in the myosin head happens.

    01:18 At this point, you will also release your ADP molecule.

    01:25 ATP then binds to it, which causes a release or a disassociation between the active site of actin and the myosin head.

    01:37 This process will then undergo a cleaving of ATP or sometimes referred to as a hydrolysis.

    01:45 That hydrolysis of ATP then provides the energy to undergo a conformational change that basically recocks the myosin head to a tension spot to have potential energy.

    02:01 Once this myosin head is in this position, it has the energy to undergo another power stroke.

    02:09 It then binds to the active site on actin as long as calcium is present, and by binding this site, it will also cause a conformational change or a power stroke.

    02:24 This process just keeps going on and on and on as long as you have enough ATP to cause the disassociation of the myosin and actin filaments, enough ATP to cause the hydrolysis of that molecule to cause the cocking of the myosin head, and as long as you have enough calcium which keeps that active site on actin open.

    About the Lecture

    The lecture Cross-bridge Cycling by Thad Wilson, PhD is from the course Musculoskeletal Physiology.

    Included Quiz Questions

    1. ADP
    2. ATP
    3. AMP
    4. UDP
    5. UTP
    1. Tropomyosin covering the active site on actin
    2. ATP binds to myosin causing the dissociation of the myosin head from the actin filament
    3. Hydrolysis of ATP allows for the cocking of the myosin head
    4. ADP molecule released during the power stroke
    5. Calcium binds to troponin C, which moves tropomyosin from the active site on the actin filament

    Author of lecture Cross-bridge Cycling

     Thad Wilson, PhD

    Thad Wilson, PhD

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