Complement System & Chronic Inflammation – Inflammation and Wound Repair

by Carlo Raj, MD

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    The complement system and how it relates to what we talked about with inflammation. Remember when I talked to you about a silly little story called strawberry and chocolate. This is opsonin. So C3b is going to opsonize the bacteria making it mighty tasty for whom? The neutrophil. Then you have anaphylatoxin C3a. C5a remember is a chemotactic factor. What does that mean? Once neutrophil comes out in interstitium, this is the GPS. It will tell the neutrophil where to go. And the MAC complex, membrane attack complex, C5 to C9 will be responsible for then boring a hole through the bacteria in which through osmotic pressure all the fluid accumulates within the bacteria and it perishes. Important complement. In complement pathologies, we'll talk about over and over again including hereditary angioedema. Meaning to say that now you've lost you C1 inhibitor. Too much complement activation resulting in oedema in the oral mucosa, inflammation, difficulty talking. Other complement pathologies that we have dealt with include paroxysmal nocturnal hemoglobinuria with the deficiency of DAF and MIIL. That's CD55 and 59 respectively. Other complement pathologies that you dealt with in microbiology. If you are deficient of MAC you are now susceptible to Neisseria species. And another important complement pathology known as your MPGN type II in which you have a nephritic factor which then stabilizes my C3 convertase. All of this we've talked about and all i'm doing is just reinforcing them. And at this point, with a review, you're thinking, Oh yeah I know this. Good. Let's continue. Cytokines involved with mediators of inflammation. We talked about interleukin-1 and TNF a part of your rolling system. Acute phase reactant. Interleukin-6 plays a pretty big role with fever along with interleukin-1. Interleukin-6, we have also looked at with what's known as your...

    About the Lecture

    The lecture Complement System & Chronic Inflammation – Inflammation and Wound Repair by Carlo Raj, MD is from the course Cellular Pathology: Basic Principles.

    Included Quiz Questions

    1. C9
    2. C3a
    3. C3b
    4. C5a
    5. C4
    1. NO
    2. IL6
    3. IL17
    4. TNF
    5. IL1
    1. Increased necrosis
    2. Increased IgG
    3. Fibrosis
    4. Increased granulation tissue
    5. Increased number of plasma cells
    1. TNF
    2. IL6
    3. NO
    4. C5a
    5. IgG

    Author of lecture Complement System & Chronic Inflammation – Inflammation and Wound Repair

     Carlo Raj, MD

    Carlo Raj, MD

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