Colon Cancer: Risk Factors, Diagnosis & Treatment

by Carlo Raj, MD

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    Our topic now is Colon Cancer It is the second most common cancer in US, 100,000 new cases annually, 6% of the population. Likewise I thought this was number 3? Yeah, it is. What do you mean? How could it be both? Well, listen. If you were to separate the genders and the sexes, males and females. Mortality Males: (1) Lung cancer (2) Prostate (3) Colorectal cancer. Females Mortality: (1) Lung cancer (2) Breast cancer (3) Colorectal cancer. So you just told me it was third. Correct, but if you combine your genders. Oh. Second most common cause of cancer in US. Okay? It's up there. Age, greater than 40. Low fiber–high fat diet. Personal history of colonic adenoma or cancer, history's big. Long standing such as inflammatory bowel disease especially ulcerative colitis, no joke. Family histories, sporadic colon cancer and HNPCC, Hereditary Nonpolyposis Colorectal Cancer. Nonpolyposis. Now, pause here for a second. I want to bring two things to light here so that we're clear moving forward. HNPCC, remember, now colorectal cancer, what do you want to do? You want to divide this into really two types. Just like we did for primary gastric adenocarcinoma, we talked about two types there. You have two types here. But the two types here literally anatomically location–wise, you have left–sided and right–sided. Left–sided, descending colon; right–sided, ascending colon. Genetically, amazingly, pay attention. HNPCC, hereditary nonpolyposis colorectal cancer, well, remember in biochemistry, in microsatellite instability, you've heard of MLH and MSH and such, that will give rise to much more so a right–sided colorectal cancer. Memorize that. Whereas if it's familial adenomatous polyposis then it will be left–sided colorectal cancer. What do you know about FAP? 100% of going on to colorectal cancer. No joke. Know the genetics here, big time. Diagnosis Slow...

    About the Lecture

    The lecture Colon Cancer: Risk Factors, Diagnosis & Treatment by Carlo Raj, MD is from the course Small and Large Intestine Diseases. It contains the following chapters:

    • Colon Cancer - Clinical Presentation
    • Colon Cancer - Diagnosis
    • Colon Cancer - Prognosis, Treatment & Prevention

    Included Quiz Questions

    1. Males - lung cancer > prostate cancer > Colon cancer Females- Lung cancer > breast cancer > colon cancer
    2. Males - Colon cancer > prostate cancer > Lung cancer Females - Colon cancer > Breast cancer > lung cancer
    3. Males - Prostate cancer > colon cancer > lung cancer Females - Breast cancer > colon cancer > lung cancer
    4. Males - Lung cancer > Prostate cancer > Gastric cancer Females - lung cancer > Breast cancer > Cervical cancer
    5. Males - Lung cancer > Gastric cancer > Prostate cancer Females - Lung cancer > Cervical cancer > Prostate cancer
    1. Smoking
    2. Low fiber diet
    3. Long-standing inflammatory bowel disease
    4. Hereditary polyposis syndrome
    5. Colorectal adenoma
    1. Colonoscopy
    2. Proctoscopy
    3. Ultrasound
    4. X-ray abdomen
    5. Sigmoidoscopy
    1. CEA
    2. Inhibin
    3. Beta HCG
    4. CA 19-9
    5. CA-125
    1. K- ras
    2. RET
    3. Src
    4. Wnt
    5. Myc
    1. Liver
    2. Bone marrow
    3. Breast
    4. Brain
    5. Spleen
    1. Regional lymph node involvement
    2. Involvement of limited to the submucosa
    3. Involvement beyond the submucosa without lymph node involvement
    4. Distant metastasis to liver
    5. Distant metastasis to brain
    1. Screening of colon cancer in FAP disease starts after 50 years of age.
    2. Screening of colon cancer starts from the age of 50 years.
    3. Screening for colon cancer is by colonoscopy.
    4. Screening for colon cancer in a patient who has a first degree relative with colon cancer is at 40 years or 10 years prior to the first degree relative.
    5. Screening for colon cancer must begin at 8 years of colon inflammatory bowel disease duration.

    Author of lecture Colon Cancer: Risk Factors, Diagnosis & Treatment

     Carlo Raj, MD

    Carlo Raj, MD

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