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Class Switch Recombination, Co-Expression and B-Cell Development – Lymphocyte Development

by Peter Delves, PhD
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    About the Lecture

    The lecture Class Switch Recombination, Co-Expression and B-Cell Development – Lymphocyte Development by Peter Delves, PhD is from the course Adaptive Immune System. It contains the following chapters:

    • Class Switch Recombination
    • Co-Expression on Naive B-Cells
    • The B-Cell Receptor
    • B1 and B2 Cells

    Included Quiz Questions

    1. IgM and IgD
    2. IgM and IgG
    3. IgG and IgD
    4. IgA and IgE
    5. IgG and IgE
    1. Signals from Helper T cells
    2. Recombination
    3. Deletion of intervening genes
    4. RNA splicing
    5. Translation
    1. The genes on the constant regions express a switch sequence (except for C delta) which enable it to produce C mu (IgM) or C delta (IgD)
    2. The constant region is attached after VJD class switching to match the appropriate immunoglobulin
    3. C delta has a switch signal which determines the expression of the rest of the genes on the constant region that determine if the immunoglobulin is IgM or IgD
    4. The VJD sequence on the immunoglobulin heavy chain controls translation of the genes required for each immunoglobulin class
    5. Signals from Helper T cells dictate which immunoglobulin will be produced on the B cell
    1. ITAMs and Src family kinases
    2. Heavy chain sequences of antibody
    3. Transmembrane sequence that holds antibody into the B cell membrane
    4. Light chain sequence of antibody
    5. Immunoglobulin class switching

    Author of lecture Class Switch Recombination, Co-Expression and B-Cell Development – Lymphocyte Development

     Peter Delves, PhD

    Peter Delves, PhD


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