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Brain blood flow or the cerebral circulation has a few unique features. Probably the most
unique is the blood brain barrier. So there is a barrier between normal blood flow that's
traveling around in the systemic circulation and that that reaches the brain. The reason for
this brain blood flow barrier is to prevent certain things from crossing over and affecting
neurons in the brain. The barrier involves a couple different processes. One of which are tight
junctions along the endothelial layer as well as these astrocyte projections. These foot-like
projections will be able to decrease the amount of flow across but that brings up another
important aspect here and that is you might need to transport a substance across the blood
brain barrier because it doesn't have fenestrations and tight junctions prevent its movement.
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This is another picture to show those foot-like projections, how it almost encases a blood
vessel and you can imagine that's very difficult to move things from the blood itself in through
these different layers, into the brain interstitial fluid and eventually the cerebrospinal fluid.
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This is helpful to prevent certain toxins from making their way in and bacterial infections.
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Other items that are important with the brain is they will increase brain blood flow base upon
what activity is going on. To relate those together, it usually has to do with the amount of
metabolism. If you're doing something like talking or reading, you are using various portions
of your brain and while you're using various portions of your brain, those spots will get more
brain blood flow. So sometimes large social interactions will even give you a little bit more
brain blood flow than very specific targeted types. Another very important aspect with
cerebral circulation is how reactive it is to carbon dioxide. Carbon dioxide causes vasodilation
of cerebrovascular bed. It also vasodilates individual vessels themselves. The opposite is also
true. In fact, if you blow off a lot of CO2 through hyperventilation you can decrease cerebral
blood flow. That is one of the reasons why if a person hyperventilates sometimes they get
lightheaded because you have decreased cerebral blood flow. Now besides vasodilation, you also
have another ability called autoregulation. Autoregulation is having a near normal blood flow
across a wide range of pressures. This is very helpful. So if you look at this graph here where
you have mean arterial pressure along the X axis and cerebral blood flow along the Y. You can
see about at 60 mmHg to maybe all the way up to 150 mmHg there's a fairly flat plateau. That
means that it doesn't matter what the blood pressure is in between 60 and 150 you're going to
get the optimal amount of cerebral blood flow. Only if pressure drops below 60 or above 150
will it fall along the normal vasculature where you just get flow depending on perfusion
pressure. The handy thing about this or why it's beneficial is that it's almost buffered from
the rest of the body. So even if pressure widely fluctuates, you'll be able to obtain optimal
amounts of cerebral blood flow. Why? Because the brain is so important, it's controlling all
the aspects of the body, you want to make sure its blood flow supply is pristinely controlled
and it also has a buffer or protectiveness to it. So you not only protect it with a blood brain
barrier, you protect it by making sure it gets the optimal amount of blood flow. That said, it is
possible in extreme conditions to overwhelm this autoregulatory system and that can happen
in times of syncope or fainting. If blood pressure gets too low, you still won't have enough
blood to perfuse the brain.