Lectures

C. Difficile Infection (Antibiotics)

by John Fisher, MD
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    About the Lecture

    The lecture C. Difficile Infection (Antibiotics) by John Fisher, MD is from the course Gastrointestinal Infections.


    Included Quiz Questions

    1. Vancomycin
    2. Ampicillin
    3. Amoxicillin
    4. Clindamycin
    5. Trimethoprim
    1. Pulsed regimen of oral vancomycin
    2. High dose intravenous vancomycin
    3. Intravenous metronidazole
    4. Oral metronidazole
    5. Oral metronidazole plus rectal vancomycin
    1. Spores picked up through contact
    2. C. difficile is not contagious, it is only due to antimicrobial treatment
    3. Through aspiration of spores
    4. Through ingestion of contaminated foods
    5. Typically spread through surgical instrumentation
    1. Tcd B
    2. Tcd A
    3. Subunit C
    4. Binery Toxin
    5. CDT
    1. Enters the cytoplasm and glycosylates RhoB protein which disrupts the actin cytoskeleton and kills the cell
    2. Binds to GM1 ganglioside on the mucosal cell surface and enters the endoplasmic reticulum
    3. Binds to Rho B protein then creates a pore in the cell wall and allows the active toxin to enter the cytoplasm
    4. Enters the cytoplasm and increases the production of cyclic AMP which causes ion transport abnormalities
    5. Enters the cytoplasm and is transported into the mitochondria through RhoB receptors which promotes an inflammatory response and cellular apoptosis
    1. Enzyme immunoassay for 2 stool specimens
    2. It is simply a clinical diagnosis
    3. Serum analysis for C. difficile toxin A
    4. It can only be confirmed by pseudomembrane biopsy
    5. Stool cultures

    Author of lecture C. Difficile Infection (Antibiotics)

     John Fisher, MD

    John Fisher, MD


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