Background – Metabolic Control of Enzyme Activity

by Kevin Ahern, PhD

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    00:01 Cells are control freaks; because they have to be control freaks.

    00:04 If they don't manage the chaos, the biochemistry going on inside of them, then they are likely to run out of energy or not have the energy they need in a critical circumstance.

    00:14 The way in which cells manage their biochemistry is through the phenomenon known as metabolic control and that will be the subject of this talk.

    00:22 In this presentation, I will go through first a background on the process and then talk about mechanisms of controlling enzyme activity.

    00:29 These include allosterism, covalent modification and control of enzyme synthesis or gene expression, as we have talked about before.

    00:39 Now metabolic control is essential. But it's important that we have our terms in agreement.

    00:44 The metabolic control that I am referring here to, refers to the mechanisms that a multicellular organism uses.

    00:50 So it's not the way that we breathe and it's not the way we run. But it's the way that our body response to the needs that's placed upon it.

    00:58 Metabolic control occurs at the cellular level; because, that's where all living processes occur.

    01:04 But it's manifested at the organismal level, as we shall see.

    01:08 The cues for metabolic control may arise in the brain, as part of the conscious process, or it may be rooted in physiology so, some examples of that.

    01:17 Adrenalin is something the fight or flight response that's initiated.

    01:21 Its initiate as part of an awareness that our brain becomes and this gives us an hormonal response.

    01:29 The cori cycle by contrast is an unconscious process that's managed between our liver and our muscle in response to exercise.

    About the Lecture

    The lecture Background – Metabolic Control of Enzyme Activity by Kevin Ahern, PhD is from the course Metabolic Control.

    Included Quiz Questions

    1. Ribozyme catalysis
    2. Allosterism
    3. Zymogen activation
    4. Regulation of gene expression

    Author of lecture Background – Metabolic Control of Enzyme Activity

     Kevin Ahern, PhD

    Kevin Ahern, PhD

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