Autoimmune Diseases

by Carlo Raj, MD

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    00:01 Let's take a look at Autoimmune diseases that affect the liver.

    00:05 It is important that you pay attention to each one of these autoimmune differentials.

    00:10 Each one will be presenting a little bit differentially and when it is time for you to indentify this particular autoimmune disease or certain markers, then they will become important for you.

    00:22 One differential for chronic liver disease of autoimmune, nature will be of autoimmune hepatitis.

    00:29 And I'll give you the markers there. Keep in mind that these individuals with autoimmune hepatitis have not touched a drop of alcohol in their entire life.

    00:39 And most likely a female.

    00:42 Auto immune diseases.

    00:44 Primary biliary cirrhosis is another disease causing eventually, damage to the liver, What I like for you to do next anatomically, is think about diseases that will be taking place within the liver and you can call these intrahepatic Or you are referring to diseases coming out of the liver Thus, extra hepatic, right? Whenever you come out of the liver, the organ system that you have immediately enter into will be the biliary system.

    01:15 So, any time you hear an attending physician or you are reading a case, and it says either inter hepatic or extra hepatic diseases Then you know exactly as to what component of the hepatic biliary system has been affected.

    01:28 With primary biliary cirrhosis, where does your biliary system begin.

    01:35 In the liver, you've heard of a caniliculi And at some point, when all of the caniliculi have come together, And you've moved towards Zone 1. Yes, you heard that correctly. zone 1, which contains your portal triad.

    01:53 And of the triad, you are dealing with your bile duct Then from there, you are going to leave your liver extrahepatic and start forming a biliary tree.

    02:04 And it is important, I give you primary biliary cirrhosis I give you auto mitochondria bodies all play a huge role there.

    02:12 We have another autoimmune disease but this is affecting more more so your biliary trees.

    02:17 And that is where your focus should be.

    02:18 Outside of the liver, extrahepatic.

    02:21 This is called primary.

    02:22 But this time it's sclerosing.

    02:24 What does sclerosis means to you? What is narrowing in primary sclerosing cholangitis? Not the blood vessel.

    02:34 It is the bile duct. Cholangeo means what in medicine? The biliary tree.

    02:39 You will be focusing upon what's known as TSC and I'll give you more of their code.

    02:45 P and K.

    02:48 Autoimmune cholangitis.

    02:49 Overlapping syndrome.

    02:51 It means to say that if you have autoimmune disease and it is causing damage to your liver, you have every possbility that this autoimmune disease may spillover to the biliary tree.

    03:03 Sarcoidosis have being here with the liver.

    03:07 I thought Sarcoidosis is only dealing with the lungs Dr. Raj? No, don't that anymore.

    03:12 You've heard of lung case of * Sarcoidosis, everyone has.

    03:17 Your patient will be most likely young African-American female but the *glenalloma could be in number of places.

    03:24 Yes, it could be in the lung, no doubt.

    03:26 But the * glanaloma can also be found in the skin perhaps.

    03:30 Or maybe down in the liver.

    03:34 P-anca Sarcoidosis causing liver disease maybe perhaps causing autoimmune nature.

    About the Lecture

    The lecture Autoimmune Diseases by Carlo Raj, MD is from the course Cirrhosis – Liver Diseases.

    Included Quiz Questions

    1. Reiter's syndrome
    2. Primary sclerosing cholangitis
    3. Overlap syndrome
    4. Sarcoidosis
    5. Primary biliary cirrhosis
    1. Non-caseating granulomas
    2. Vanishing of bile ducts
    3. Inflammation of the portal triads
    4. Onion skinning of the bile duct
    5. Intrahepatic cholestasis

    Author of lecture Autoimmune Diseases

     Carlo Raj, MD

    Carlo Raj, MD

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    So and so
    By Eleftherios B. on 15. February 2019 for Autoimmune Diseases

    Speaks too fast Could include more detail Pronunciation was a little bit strange