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ATP Synthase

by Georgina Cornwall, PhD
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    00:00 Here we are. We are at the staircase. The girls have gone down and in. They are on the inside in the mitochondrial matrix. And we have lots of boys hydrogen ions outside and they are angry.

    00:12 They are looking for a way back in. They are wondering around in the alley all upset and they find ATP synthase, which is a revolving door. So this door will spin as they rush through it and because they are coming back in with so much energy, to meet up with their electrons, the door spins really really fast.

    00:32 And its that spinning of the door that allows phosphorylation of ADP into ATP.

    00:39 So hydrogen ions rush through the ATP synthase. It causes it to spin which is realistically what happens.

    00:46 There are lots of different subunits on this protein that will spin around.

    00:51 And it's the energy of them spinning around that allows ATP to be formed from ADP and inorganic phosphates that are floating around. So to put this all together, let's see we have our electron transport chain, electrons have bumped down from one molecule to the other. Hydrogen ions have been shot out into the back alley or the intermembrane space. Oxygen picked up the electrons and now it really needs to be balanced by picking up some hydrogens. So we have 2H per 1/2 O2 which is per oxygen. And we form an H20.

    01:33 So, in this case we have oxidative phosphorylation driven by electron acceptor. Oxygen pulling electrons down stairs.

    01:45 And we also have chemiosmosis because hydrogen ions were forced out into the intermembrane space and rushed back through the ATP synthase in order to generate our ATP. So, you can see where the carbons have been made in the whole process or where the carbons left the process.

    02:08 You can see what happened with all the electron transporters or all the taxis.

    02:12 And you can see how much ATP is being made. So as we look at the equation for cellular respiration, you can now see that we have carbon dioxide being evolved. You know where each of those carbons come from. You had 2 coming out in pyruvate oxidation. And the other 4, coming out during the Krebs cycle.

    02:34 You can now see that we have water manufactured at the very end of the electron transport chain and chemiosmosis.

    02:42 And as a result of all of that, we have tons of ATP made. Now, a lot of ATP is captured but naturally we're going to lose some as heat


    About the Lecture

    The lecture ATP Synthase by Georgina Cornwall, PhD is from the course Energy, Enzymes and Metabolism.


    Included Quiz Questions

    1. a difference in H+ concentration on the two sides of the inner mitochondrial membrane.
    2. Pi transfer through the plasma membrane.
    3. osmosis of macromolecules.
    4. large quantities of ADP.
    1. C6H12O6 + 6O2 → 6CO2 + 6H2O + Energy (Heat + ATP)
    2. C6H12O6 + 6O2 → 6CO2 + 6NADH + 3FADH2 + Heat
    3. C6H12O6 + 6O2 → 6CO2 + 12NADH + Heat
    4. C6H12O6 + 6O2 → CO2 + H2O + Energy (ATP + NADH + FADH2)
    5. C6H12O6 + 6CO2 → 6O2 + 6NADH + 3FADH2 + 6H2O

    Author of lecture ATP Synthase

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD


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