Atherosclerosis: Demand

by Carlo Raj, MD

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    00:01 It is going to the demand.

    00:02 Now this is important for us because ultimately this takes us into the concept and explanation for management. With management, what might you want to do? You might want to try to do something to vasodilate and improve the perfusion to the heart in terms of supply, or what about demand? What if the demand is too much? What if the demand for oxygen by the heart is too much? What might you want to do with the demand please as one of your objectives? It is to make sure that you decrease the demand enough. What does demand mean to you? The demand side basically has two major things. Number 1, the heart rate. So, the faster that the heart then works, the more energy that it then requires in the form of what? ATP. How do you form ATP in the mitochondria? I believe it is called what? Electron transport chain or oxidative phosphorylation.

    00:52 And this all begins with the process of what? Glycolysis and TCA cycle then feeding into your the ETC, but you must have oxygen there. The point is now you have too much demand may be because of increased heart rate or the pumping. How hard is it pumping? The resistance or blood pressure is what you are referring to. Ultimately the tachycardia and high blood pressure increases the myocardial oxygen demand that what might you want to do in this patient when the demand is too much? You do everything in part to make sure that you slow down. And so may I ask you something? How much do you want to decrease your heart rate? It is called beta-blocker. What might you want to do in terms of your blood pressure? Try to decrease it. So these are things that are you going to be paying attention to as we continue through our lecture series. What are those modifiable risk factors? Smoking.

    01:44 Try to prevent your patient from smoking or if the patient already started smoking, to quit the smoking whatever the cessation methodologies might be. Hypertension, hyperlipidemia, diabetes.

    01:56 Metabolic syndrome.

    About the Lecture

    The lecture Atherosclerosis: Demand by Carlo Raj, MD is from the course Atherosclerosis.

    Included Quiz Questions

    1. Beta blockers
    2. Calcium channel blockers
    3. Thiazide diuretics
    4. Loop diuretics
    5. Alpha blockers

    Author of lecture Atherosclerosis: Demand

     Carlo Raj, MD

    Carlo Raj, MD

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