Aspartate Family and Asparagine Metabolism

by Kevin Ahern, PhD

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    The next stem we'll be considering our reactions is that of the aspartate family. The aspartate family, as its name suggests, all involve aspartate. And aspartate can actually trace its roots back one further molecule and that's oxaloacetate as you can see here. All family members in this metabolic pathway come from aspartate. Aspartate can actually also be made from one of them. So there's reversed reaction that can produce aspartate as we will see. There are numerous ways that lead to aspartate. So I'm only going to talk about a couple of them. One of the ways and one of the more common ways in which aspartate can be made is by the process of transamination that we've already talked about. Here's one sample transamination and there are many different transaminations that can produce aspartate. One starts with glutamate and oxaloacetate. Glutamate being the amino acid that is the source of the amine. Oxaloacetate being the alpha keto acid which is the source of the oxygen. The product of that transamination, the glutamate becomes alpha-ketoglutarate, and the oxaleacetate becomes aspartate. Amine has come from the glutamate, onto the aspartate, the oxygen has come from the oxaloacetating, becomes the alpha-ketoglutarate. Another way of making aspartate is by hydrolysis. This is a reversal of the synthesis of asparagine in a way. Now, we'll see later, it's not the exact reversal of the synthesis of asparagine. Asparagine can be cleaved using water in a hydrolysis reaction to produce aspartate and there's that ammonium ion again. Ammonia is a toxic compound. The cell meets the aspartate, they're going to do this reaction. If the cell was breaking down asparagine, it's got too much asparagine, he'll do this reaction. But that ammonium ion has to be gobbled up somewhere or it's going to cost...

    About the Lecture

    The lecture Aspartate Family and Asparagine Metabolism by Kevin Ahern, PhD is from the course Amino Acid Metabolism. It contains the following chapters:

    • Aspartate Family
    • Aspargine Metabolism

    Author of lecture Aspartate Family and Asparagine Metabolism

     Kevin Ahern, PhD

    Kevin Ahern, PhD

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