00:00 Okay, let's take a look at a question here. 00:04 The President returns from a first trip to Cuba. 00:08 First time a president has visited Cuba in 50 years. 00:12 He presents with fevers, dehydration and nausea. 00:14 A blood smear shows plasmodium falciparum schizonts. 00:18 The following drugs are schizonticides except: Choloroquine dihydroarteminisin Quinine Halofantrine Sulfonamides You chose halofantrine. 00:40 Which drug would be effective in treating amebiasis in the liver? Diloxanide furoate Iodoquinol Paromomycin Metronidazole Good, you chose metronidazole. 01:03 So remember metronidazole is particularly effective in systemic infection and it's effective in the liver. 01:09 And we treat severe intestinal infections and liver abscess is the same with respect to amoeba type infections. 01:20 The principle behind amebicidal therapy is understanding where each drug works. 01:25 The first three drugs are luminal amebicides. 01:29 They stay in the lumen of the gut and work very well there. 01:32 If the infestation is at the luminal surface that is. 01:35 Once the organism becomes systemic, metronidazole would be the logical choice. 01:40 As it's activated by anaerobes and it's very, very effective in hepatic tissues. 01:48 While on mission with Medecins sans Frontieres or Doctors without Borders, you see a young boy with a strange lump in his retina. 01:56 It is a small cyst with a hard center. 02:06 What would be the appropriate treatment for that finding? Niclosamide Praziquantel Mebendazole Albendazole. 02:18 Good, you chose aldbendazole. 02:19 So the image is a typical presentation of retinal cysticercosis. 02:25 The larval stage of pork tapeworm. 02:28 Niclosamide does not kill pork tapeworm in this stage. 02:32 It only kills it in the cestode stage. 02:35 Praziquantel should never be used in ocular cysticercosis because the destruction of the organism can actually cause permanent ocular lesions. 02:46 Mebendazole is not systemically absorbed to any great a deal any great degree and it's therefore not a great choice. 02:54 Albendazole is the drug of choice in ocular cysticercosis. 03:00 That's it. 03:02 You made it through this lecture. 03:03 You did really well. 03:05 I'm glad to say that nobody got sick looking at these wonderful pictures. 03:09 And you made it through our pharmacology lecture. 03:10 So kudos to you. 03:12 Go write your exam. 03:13 Show them what you know.
The lecture Questions – Antiprotozoal and Anthelmintic Drugs by Pravin Shukle, MD is from the course Antimicrobial Pharmacology.
Which statement is correct regarding the management of amebic liver abscess?
Which pairing is correct?
5 Stars |
|
5 |
4 Stars |
|
0 |
3 Stars |
|
0 |
2 Stars |
|
0 |
1 Star |
|
0 |