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Introduction – Antigen Processing and Presentation

by Peter Delves, PhD
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    The vast majority of T-cells that is the alpha-beta (αβ) T-cells, need to see antigen that is processed and presented to them. So let’s explore together exactly what is meant by antigen processing and presentation. So T-cells recognize protein antigens that are processed into peptides. And what that means is that protease enzymes chop up the polypeptide chain into short stretches of amino acids - peptides. These peptides are then shown to the T-cell receptor or presented to the T-cell receptor by MHC molecules. So the peptide is put together with the MHC, and this combination of peptide-MHC is what the αβ T-cell needs to recognize....

    About the Lecture

    The lecture Introduction – Antigen Processing and Presentation by Peter Delves, PhD is from the course Adaptive Immune System.


    Included Quiz Questions

    1. Antigens would not be processes into peptides, T cells with an alpha-beta TCR would be unable to recognize them
    2. Antigens would not be processed into peptides, T cells with an alpha-beta TCR would have to aggregate to recognize them
    3. T cells could not recirculate in the immune system
    4. Antibodies could not be produced
    5. Antigens the size of peptides or smaller would not be recognized by T cells

    Author of lecture Introduction – Antigen Processing and Presentation

     Peter Delves, PhD

    Peter Delves, PhD


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