00:01 The vast majority of T-cells that is the alpha-beta (αβ) T-cells, need to see antigen that is processed and presented to them. 00:09 So let’s explore together exactly what is meant by antigen processing and presentation. 00:15 So T-cells recognize protein antigens that are processed into peptides. 00:22 And what that means is that protease enzymes chop up the polypeptide chain into short stretches of amino acids - peptides. These peptides are then shown to the T-cell receptor or presented to the T-cell receptor by MHC molecules. So the peptide is put together with the MHC, and this combination of peptide-MHC is what the αβ T-cell needs to recognize.
The lecture Introduction – Antigen Processing and Presentation by Peter Delves, PhD is from the course Adaptive Immune System.
Which of the following best describes the role of proteases in antigen presentation to T cells?
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