Review – Antidepressants

by Pravin Shukle, MD

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    00:01 So in review, let's just go over what we talked about.

    00:05 In major depressive disorder.

    00:07 You can use any of these agents.

    00:10 The newer agents like the SSRIs and the SNRIs have fewer side effects.

    00:16 But they are not necessarily more effective than, say, the tricyclic antidepressants. Remember that you can have side effects that include psychomotor sedation with tricyclics.

    00:25 You can also get sleep disturbances in using drugs like the serotonin antagonist like like trazodone.

    00:33 But sometimes we will use that to our benefit and use it as a sleep aid. Selective agents may be used more predominantly in parkinsonism like selegiline.

    00:45 You can use it in smoking cessation like bupropion.

    00:48 You can use it in chronic pain syndromes like amitriptyline, duloxetine and venlafaxine, and you can use it in diabetic neuropathy like duloxetine.

    00:57 So all of these drugs are excellent drugs.

    01:01 Some of them are more excellent than others in certain disease states.

    About the Lecture

    The lecture Review – Antidepressants by Pravin Shukle, MD is from the course CNS - Pharmacology.

    Included Quiz Questions

    1. Amitriptyline is indicated for chronic pain.
    2. Tricyclic antidepressants have fewer side effects than selective serotonin reuptake inhibitors.
    3. Selegiline is often indicated for smoking cessation.
    4. Tricyclic antidepressants are rarely indicated in major depression.
    5. Duloxetine is not recommended for diabetic neuropathy.

    Author of lecture Review – Antidepressants

     Pravin Shukle, MD

    Pravin Shukle, MD

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