Overview – Anti-Seizure Medications

by Pravin Shukle, MD

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    Welcome to pharmacology by Lecturio. I'm Dr. Pravin Shukle. Today, we're going to talk about some anti-seizure and anti-epileptic medications. The principal behind anti-epileptic treatment is to ensure that we're going to be blocking the transmission of neurotransmitters into the synaptic cleft within the central nervous system. We have many ways of doing that. The first way to do that is by blocking sodium channels. Now, you can see sodium channels are present in the terminal button at the top of that diagram there. Sodium channel blockade is a rate dependant process and doing so gives us a prolonged refractory period. We have many medications that can cause a blockade of the sodium channel. The most commonly used is phenytoin, also called Dilantin. Now, other medications include carbamazepine, and we also have drugs like lamotrigine which can block the sodium channel. Newer drugs have come out onto the markets as well and you can see them listed there. Those aren't as important for your exams, but certainly they are now going to be I think the standard of care going forward. The second way that we can affect epileptic activity in the brain is by acting on the GABA channel. Remember that benzodiazepines increase the frequency of opening of the GABA channel, allowing chloride to enter into the cell. Barbiturates also act on the GABA channel by increasing the duration of opening of that channel. Now, here is the GABA receptor. This illustration clearly shows that benzodiazepines and barbiturates both act on this channel to help move chloride across the membrane. GABA potentiation can increase the activity of GABA as well. This isn't acting directly on the channel but actually acting on the molecules. Topiramate and valproic acid are two of these agents that can help potentiate the activity of...

    About the Lecture

    The lecture Overview – Anti-Seizure Medications by Pravin Shukle, MD is from the course CNS - Pharmacology.

    Included Quiz Questions

    1. …cocaine.
    2. …amphetamine.
    3. …dopamine.
    4. …methylphenidate.
    5. …epinephrine.
    1. All of the answers are correct.
    2. Ethosuxamide
    3. Retigabine
    4. Phenytoin
    5. Valproic acid
    1. BDZ increases frequency of opening, while barbiturates affect duration of opening.
    2. BDZ increases the refractory period, while barbiturates decrease reuptake of GABA.
    3. BDZ works via calcium channel blockade, while barbiturates work via potassium channel activation.
    4. BDZ works via increasing release of GABA, while barbiturates decrease reuptake of GABA.
    5. BDZ works via Sodium channels blockade while barbiturates work via potassium channel activation.

    Author of lecture Overview – Anti-Seizure Medications

     Pravin Shukle, MD

    Pravin Shukle, MD

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