Amphetamines – Drugs of Abuse

by Pravin Shukle, MD

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    Amphetamines are very commonly abused in society today. We have dextroamphetamines, methamphetamines and crystal methamphetamine which is very commonly abused in the United States and around the world. Amphetamine alters the transport of CNS amines like dopamine, norepinephrine and serotonin. Initially, amphetamines cause euphoria. People feel great. They feel self-confident. They feel particularly alert. And it becomes a very very addictive kind of sensation. Overdose includes restlessness, agitation, tachycardia, hyperthermia, hyperreflexia and seizures. And long term chronic use results in psychosis including delusions and paranoia. And one of the most worrisome thing that we started to see now, particularly with crystal meth, is necrotizing arteritis cerebral hemorrhage and renal failure. There are other types of cogeners of amphetamines which are making the marketplace particularly crowded. There is DOM, also known on the street as STP. Now, this drug was first invented in 1963 by a chemist by the name of Alexander Shulgin. He actually gave away a whole bunch of STP in 1967 in Haight Ashbury district of San Francisco. What ended up happening was all these people showed up in emergency departments with this very bizzare kind of syndrome and it took us a long time to figure out what it was. This drug has a very long duration. It causes pupillary dilatation, hypertension, increased sexual drive and hallucinations. One of the most common new cogener of amphetamine is MDMA or ecstasy. Now, we're starting to get into a new class of drugs that are locally called designer drugs. MDMA or ecstasy is more selective on serotonin than regular amphetamines. Users think that it facilitates interpersonal communication. People feel like they can talk forever when they take this drug. They feel like they're warm and fuzzy towards each other. And it's often used as a sexual enhancer. PET scans...

    About the Lecture

    The lecture Amphetamines – Drugs of Abuse by Pravin Shukle, MD is from the course Toxicology.

    Included Quiz Questions

    1. Necrotizing arteritis
    2. Aneurysm
    3. No findings, crystal meth is a safe drug.
    4. Calcified atherosclerosis
    5. Arteriosclerosis
    1. Hyperthermia
    2. Hypothermia
    3. Acute Alzheimer's disease
    4. Necrotizing arteritis
    5. Wandering bladder
    1. Serotonin reuptake inhibitor and releasing agent
    2. Serotonin releasing agent
    3. Serotonin reuptake enhancer
    4. Dopamine reuptake inhibitor
    5. Norepinephrine reuptake inhibitor and releasing agent

    Author of lecture Amphetamines – Drugs of Abuse

     Pravin Shukle, MD

    Pravin Shukle, MD

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