Amiodarone Induced Thyroiditis – Hyperthyroidism (Thyrotoxicosis)

by Carlo Raj, MD

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    Amiodarone Induced Thyroiditis, with this it could be… patient may present either with hypo or hyperthyroidism, structure resembled that of your thyroid hormone because it contains iodine, seen in approximately 3 percent of amiodarone, 1 to 3 years of therapy, thyroid is not enlarged or tender, can cause both hypo and/or hyperthyroidism. Hypothyroidism by blocking the peripheral conversion of T4 to T3, hyperthyroidism because literally the thyroid feels as though that it is increasing its uptake of iodine. Low blood flow on color flow Doppler thyroid ultrasound is what you are thinking of in general with thyroiditis. Take a look at Riedel. With Riedel’s thyroiditis, we called this fibrous. It is a primary fibrosing disorder, if you then take a look at the picture on the right. On the far right, a remnant of or sparing of a little bit of your thyroid histology whereas on the left, you are seeing quite a bit of fibrosis taking place of your thyroid gland. So, now, two different things that are taking place in a thyroid gland, earlier referred to granulomatous and that would be more or less your subacute type, maybe viral infection and with viral infection, you are thinking about painless or painful, excuse me, whereas if it is painless and a silent lymphocytic infiltration, this is primary fibrous in disorder. Women, much more so than men, elderly, dense fibrosis, that replaces the normal thyroid parenchyma with macrophage and eosinophil infiltration. Fibrosis, once again, take a look at the picture histologically on your left, would be areas of that fibrosis which is then replacing any type of thyroid normal tissue that may exist. Meaning to say, the far right in that homogenous pink region represents your colloid. The fibrosis invades the adjacent structures and that is important for you to...

    About the Lecture

    The lecture Amiodarone Induced Thyroiditis – Hyperthyroidism (Thyrotoxicosis) by Carlo Raj, MD is from the course Thyroid Gland Disorders.

    Included Quiz Questions

    1. It is structurally similar to thyroid hormone and contains iodine
    2. Binds TBG, increasing free thyroid hormone in serum
    3. Up regulates TSH receptors
    4. Structurally similar to TRH, stimulates release of TSH
    5. Rapidly converts T4 to T3
    1. Riedel's thyroiditis
    2. Amiodarone induced thyroiditis
    3. Subacute thyroiditis
    4. Acute infectious thyroiditis
    5. Silent thyroiditis
    1. Fibrosis and eosinophilia
    2. Diffuse enlargement of anterior neck
    3. Older patients
    4. Cystic nodules filled with excessive colloid
    5. Hemorrhage into cysts

    Author of lecture Amiodarone Induced Thyroiditis – Hyperthyroidism (Thyrotoxicosis)

     Carlo Raj, MD

    Carlo Raj, MD

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