Lectures

Amino Acid Catabolism

by Kevin Ahern, PhD
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    Now as we consider amino acid catabolism, I’ve talked about some of the individual reactions, but I want to now describe them in the entirety of the picture of all the amino acids. Amino acid catabolism is broken down to three categories. The first category being amino acids that are glucogenic. These are amino acids that are broken down into glycolysis or gluconeogenesis intermediates. And the glucogenic amino acids are shown in the figure on the right labeled in green. The ketogenic amino acids are those that are broken down to form acetyl-CoA. And they’re shown in the figure on the right on the red. There are still amino acids that appear as intermediates in both pathways and they’re known as ketogenic and gluconeogenic. And those amino acids are shown in the pathway in blue. Now the pathways that are shown on the right schematically depict on the left, the glycolysis pathway starting with glucose and ending with pyruvate. And the circle on the right depicts the citric acid cycle and the intermediates of the citric acids cycle. So we can see how the breakdown of these amino acids feed into these individual pathways. The glucogenic amino acids, you can see here, alanine, I won’t describe them all. You can see the list of amino acids that are present. The ketogenic amino acids are not nearly as a bond, but there’s only two that primarily produce the acetyl-CoA, lysine and leucine. And here are the amino acids that are involved in both. Yeah, it’s complicated. It looks complicated. But there’s actually some simplification to it. And that is that there are only six molecules that are involved in the catabolism of amino acids They’re shown here. Pyruvate, acetyl-CoA, oxaloacetat, alpha-ketoglutarate, succinyl-CoA and fumarate. All of the animo acids can be...

    About the Lecture

    The lecture Amino Acid Catabolism by Kevin Ahern, PhD is from the course Amino Acid Metabolism. It contains the following chapters:

    • Amino Acid Catabolism
    • Amino Acids Modified After Incorporation Into a Protein

    Included Quiz Questions

    1. Glucogenic amino acids include those broken down into pyruvate and oxaloacetate.
    2. Ketogenic amino acids break down to ketone bodies, such as acetone.
    3. Most amino acids are ketogenic.
    4. All of the answers are true.
    5. None of the answers are true.
    1. Transamination is the most common mechanism
    2. Brain levels of ammonia are kept high.
    3. Glutamine accepts ammonia from many sources.
    4. All of the answers are true.
    5. None of the answers are true.
    1. ...involves phosphorylation of serine and threonine.
    2. ...involves carboxylation of arginine.
    3. ...results in glycosylation of proline.
    4. All of the answers are true.
    5. None of the answers are true.

    Author of lecture Amino Acid Catabolism

     Kevin Ahern, PhD

    Kevin Ahern, PhD


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