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Amebicides – Antiprotozoal Agents

by Pravin Shukle, MD
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    Okay, so that's the antimalarial agents in a nutshell. Let's move on to the amebicides. Now amebicides are going to be divided into two different groups. Those amebicides that act systemically in the tissues and those are for people with systemic infections. And those amebicides that acts exclusively in the bowel wall. And those are people who have more GI limited disease. Now you can say that agents are very similar to the anti-malarial agents. Chloroquine, metronidazole, tinidazole. These are all agents that you've seen before. Luminal amebicides act on organisms on the bowel wall itself. So these are the agents here that you can see that we use for luminal agents. And we'll go through each of them in detail. Let's start off with the emetines. So the emetines are a group of drugs that block ribosomal movement along the messengerRNA. So this is kind of an interesting visual idea. Imagine that that messengerRNA is a long railroad track. The ribosome is a kind of like a car on a train that just travels along the track. And as it travels along the track it reads different codes in the messengerRNA and produces a protein. The movement of that ribosome along the railroad track is blocked by this class of drugs. And by that method inhibits proteins synthesis specially for organisms like amoeba. In terms of toxicity, there's quite severe toxicity with these agents and it's actually extremely common. GI distress is going to be the number one type. You can also sometimes get muscle weakness. And in terms of cardiac muscle, you can get arrhythmia, and congestive heart failure. So be very aware of the side effects of these medications. The other agents that we use to kill, to act as amebicides are metronidazole and tinidazole. So we...

    About the Lecture

    The lecture Amebicides – Antiprotozoal Agents by Pravin Shukle, MD is from the course Antimicrobial Pharmacology. It contains the following chapters:

    • Amebicides
    • Amebicides: Overview of Treatment

    Author of lecture Amebicides – Antiprotozoal Agents

     Pravin Shukle, MD

    Pravin Shukle, MD


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