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Acute Disseminated Encephalomyelitis, Transverse Myelitis and Central Pontine Myelinolysis

by Carlo Raj, MD
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    Our topic here is acute disseminated encephalomyelitis. So, what does this mean to you? If you take a look at the picture here, were affecting the spinal cord and were affecting the parenchyma, as well of the brain. It’s a monophasic demyelinating disease that most commonly will be following a viral infection or a patient has received immunization. That’s important. It’s got acute disseminated encephalomyelitis. Please look for a viral infection, and then following which may result in a demyelinating disease. Symptoms develop a week or two after the antecedent infection. Diffuse brain involvement: headache, lethargy, coma in some cases. Prognosis: Well, here, recovery typically near complete, thank goodness, because here for the most part, as long as you’re able to properly provide the supportive therapy for the viral infection, then perhaps, this particular issue goes away. Less than one-third, however, will go on to multiple sclerosis in the future. So, keep that in mind as well. We want to think of this of being, perhaps, something like pre-multiple sclerosis, if that helps you. This one's important, pay attention to ADE viral infection. This is transverse myelitis. I’ll give you one clinical pearl. Stay away from the brain in this condition, okay? The reason I say that is if you say myelo-, you’ll notice there’s no encephalo-. In addition, take a look at the schematic here. There’s no brain pictured here on purpose. So, it’s the demyelinating event restricted to the spinal cord. Way back when, when we talked about spinal cord pathology or when you have reviewed it, we talked about transverse myelitis as being a possible cause of trauma to the spinal cord. Here you have it. There’s no evidence of brain lesion. That is the absolute clinical pearl that you want to take out of this. It...

    About the Lecture

    The lecture Acute Disseminated Encephalomyelitis, Transverse Myelitis and Central Pontine Myelinolysis by Carlo Raj, MD is from the course Multiple Sclerosis. It contains the following chapters:

    • Acute Disseminated Encephalomyelitis
    • Central Pontine Myelinolysis

    Included Quiz Questions

    1. Sjogren's syndrome
    2. Rheumatoid arthritis
    3. Systemic lupus erythematosus
    4. Scleroderma
    5. Wegener's granulomatosis
    1. Acute disseminating encephalomyelitis
    2. Central pontine mylelinosis
    3. Transverse myelitis
    4. Japanese encephalitis
    5. Syringomyelia
    1. Central pontine myelinosis
    2. Transverse myelitis
    3. Acute disseminated encephalomyelitis
    4. Hydrocephalus
    5. Wernicke's encephalopathy

    Author of lecture Acute Disseminated Encephalomyelitis, Transverse Myelitis and Central Pontine Myelinolysis

     Carlo Raj, MD

    Carlo Raj, MD


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