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Action of Transamidase – Beta Lactam Antibiotics

by Adam Le Gresley, PhD
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    The lecture Action of Transamidase – Beta Lactam Antibiotics by Adam Le Gresley, PhD is from the course Medical Chemistry.


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    1. …serine amino acid.
    2. …alanine amino acid.
    3. …tryptophan amino acid.
    4. …glycine amino acid.
    5. …methionine amino acid.
    1. During cross-linking process, the penicillin-binding proteins get incorporated into the bridge structure.
    2. The penicillin-binding protein attacks the carbonyl carbon of the amide group between terminal D-ala-D-ala units.
    3. After the formation of a cross-linking between two peptide chains, the penicillin binding protein gets free to start new cross-linkage steps.
    4. After the removal of D-alanine unit, the neighboring pentaglycine unit from the other NAM-NAG polysaccharide chain attacks the carbonyl carbon via an addition-elimination reaction.
    5. The PBP forms an ester group with the second alanine amino acid of the peptide chain and kicks off the first D-alanine unit from peptide chain.
    1. …the geometrical resemblance of penicillin molecule to an acylated D-alanine-D-Alanine dipeptide.
    2. …the geometrical resemblance of penicillin molecule to pentaglycine chain.
    3. …the geometrical resemblance of penicillin to serine amino acid present in the active site of PBP.
    4. …the geometrical resemblance of penicillin to NAM units.
    5. …the geometrical resemblance of penicillin to NAG units.

    Author of lecture Action of Transamidase – Beta Lactam Antibiotics

     Adam Le Gresley, PhD

    Adam Le Gresley, PhD


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