Move on to achalasia.
We’ve now, we’ve completed discussion of our
infectious esophagitis, we did our reflux esophagitis
and here, we’ll take a look at obstruction with
achalasia of your lower esophageal sphincter.
It doesn’t wish to relax.
If you’ve lost ability to relax your
lower esophageal sphincter… how?
We’ll get into that.
There’ll be two major pathways.
One will be acquired,
one will be genetic.
And you’ll like it.
And if that does… if the lower esophageal sphincter doesn’t
wish to open, then what happens proximally in the esophagus?
And you know that you’ve heard
of the term bird’s beak.
Now the bird’s beak would be the distal end of the
esophagus that gives you like a beak, a smooth tapering.
But this, proximally, the head of the bird,
we need to say, ‘with the dilation part’.
It’s a proximal dilation and you have the
smooth tapering, upon your barium swallow.
Functional obstruction of LES causes dysphagia to
both, to both solids and liquids at the same time.
Endoscopy, not a good test for diagnosis because you can’t
really see the issue with the lower esophageal sphincter
and so that’s kind of different from really, any other
type of pathology that we’ve seen in the esophagus.
Endoscopy has been quite a bit of the definitive
diagnosis or the definitive tool, tool for diagnosis.
Dealing with esophageal cancers, dealing
with strictures, and so on and so forth.
So therefore here, you’re going
to be doing a pressure test.
Take a look at the
cartoon on the left.
The cartoon on the left is literally
showing you the diaphragm there,
but then the lower esophageal sphincter
which does not want to open.
And so therefore with that increased constriction
or lack of relaxation of lower esophageal
sphincter; if you take a look at the imaging study
on your right, you’ll notice this same cartoon on
your left is manifested on the right as being the
bird’s head with proximal dilation and notice at
the very end here, on the bottom right, there’s
smooth tapering, in other words your bird’s beak.
This is achalasia.
Do not confuse this with reflux.
Could there be reflux
associated with this?
Sure, but my goodness, not as extensive
as what you would find with GERD.
Here the problem is, the lower esophageal
sphincter doesn’t want to relax.
Now, let’s talk about why your lower
esophageal sphincter doesn’t wish to relax.
Give me some peptides that you know of that are responsible
for normal relaxation physiologically of the LES.
Nitric oxide, maybe VIP - Vasoactive
Intestinal Peptide, and nitric oxide.
What if these were
absent in your patient?
Well, gone is the relaxation
of LES, welcome to achalasia.
Esophagogastroduodenoscopy necessary to rule
out… EGD is necessary to rule out achalasia
due to secondary causes such as gastric
cancer cardia or perhaps even Chagas disease.
So you need to make sure that you get in
there and rule out other issues, because your
patient is going to be complaining of dysphagia
to solids and liquids, non-progressive.
Cancer is important
for you to rule out.
[Laughs] My goodness!
Chagas could in fact cause achalasia.
Now what Chagas means is the following; you’re taking
a cruise-- I’m being silly here but this will help.
You’re taking a cruise
down to South America.
You end up acquiring an infection
known as Trypanosoma Cruzi.
South America, Trypanosoma Cruzi,
resulting in Chagas disease.
Chagas disease for you, and I keep repeating this,
will be responsible for 3 major sites for pathology.
One would be the esophagus with achalasia,
dilation of the proximal esophagus.
Chagas with amastigotes in the heart destroying the
myocardium, resulting in dilated cardiomyopathy.
Chagas disease down in the intestine.
Trypanosoma Cruzi resulting
in toxic megacolon.
Dilation, dilation, dilation.
Chagas, Chagas, Chagas.
Chagas, Chagas, Chagas.
Three different locations big time
that you want to pay attention to are
Chagas, Trypanosoma Cruzi, what was the
amastigote that I told you about?
In microbiology, you should know
the amastigote phase for some of
these organisms, because this is what they’re going to give you.
They’ll give you a picture of amastigotes
in the myocardium, and you should be...
you should know that is what it is, resulting
in a dilated type of cardiomyopathy.
The chest X-ray may show a fluid level
in the chest with absent gastric bubble.
Because you can’t even
get anything in there.
The lower esophageal sphincter
doesn’t wish to relax.
So what is the confirmatory
test for achalasia?
It is not endoscopy.
Remember, you are going to do an EGD to
rule out important causes perhaps, right?
However, the manometry measures
the pressure within the esophagus.
In the upper portion of your esophagus, when you eat
a bolus or consume a bolus, it enters esophagus.
What then happens with pressure?
What should happen physiologically
down the lower esophageal sphincter?
It should relax.
It’s called receptive relaxation.
In achalasia, the lower esophageal
sphincter does not relax.
That’s your problem,
Endoscopic pneumatic dilation would be perhaps
necessary but management here and risk, every
possibility that you may dilate your esophagus
too much resulting in rupture; number one.
Number two, with management, another option
would be actually to inject botulinum.
You know about botox, amazing.
But point is, people are actually injecting
this so that they can then inhibit the release
of acetylcholine from the neuromuscular junction
to get away, or to remove the wrinkles.
Well, same concept, but
now where are you?
The esophagus, causing well, hopefully maybe perhaps
to assist with relief and to bring about relaxation.
There’s something called the
Heller myotomy, a myotomy.
Then now at this point, you’re thinking
about maybe, maybe relaxing the lower
esophageal sphincter by literally
removing parts of the muscle - a myotomy.
Also keep in mind that you have calcium
channel blockers for antagonist.
And PPIs are useful
adjuncts to therapy as well.
Adjuncts because you’re trying to, number
one, create relaxation and at the same time
remember, any type of lesion down by the distal
esophagus, you’re always worried about reflux.
So PPIs become an important