Acetylsalicylic Acid (ASA)

by Pravin Shukle, MD

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    Let's talk in detail about aspirin or ASA. ASA is your prototypical cyclooxygenase inhibitor and in fact it was probably one of the first drugs that was commercially available in the world. Now COX-1 is found in non-inflammatory cells, and COX-2 is found in activated lymphocyte, polymorphonuclear cells and other inflammatory cells. Aspirin reduces thromboxane and prostaglandin formation in the body. Aspirin irreversibly inhibits COX-1 and 2. So, non-steroidal anti-inflammatory agents are reversible, aspirin is irreversible. And I'm gonna say this again because I want you to get that into your brain. Aspirin irreversibly inhibits COX-1 and 2. Low dose aspirin less than 325 milligrams, works on platelet aggregation. Medium dose aspirin, between 325 and 1250 milligrams a day, have antipyretic and significant analgesic effects. In high dose, that's 1250 and 4000 milligrams a day, have a strong anti-inflammatory effect. I was hospitalized with pericarditis after my trip to the Amazon, and the thing that worked the best for me was 650 milligrams twice daily of aspirin. It was a very effective anti-inflammatory agent, and I use it almost exclusively in severe inflammatory conditions like pericarditis. Now, aspirin works quite well to reduce inflammation without reducing immunity. It does not effect regular tissues, which is why we like it so much. It reduces prostaglandin synthesis in the central nervous system, so that's why it has an anti-fever or antipyretic activity. It's also a great analgesic. We don't know why it works so well as an analgesic, but we know that patients who take aspirin, have reduced pain sensor activity through prostaglandin. It may work through a central mechanism as well but we haven't quite figured that out yet. That's suprising considering the drug is a 180 years old. The drug has a half life of about 5 hours. And it's...

    About the Lecture

    The lecture Acetylsalicylic Acid (ASA) by Pravin Shukle, MD is from the course Inflammation Pharmacology.

    Included Quiz Questions

    1. Aspirin irreversibly inhibits COX-2 while other NSAIDs reversibly inhibit COX-2.
    2. Aspirin inhibits platelet activation while other NSAIDs inhibit platelets and the coagulation cascade.
    3. Other NSAIDs inhibit the formation of cytokines while Aspirin does not.
    4. In general, patients have a higher tolerance for aspirin compared to other NSAIDs.
    5. Children can receive aspirin safely and should NOT receive other NSAIDs.
    1. Inhibits phagocyte activity in neutrophils.
    2. Inhibits platelet activation
    3. Inhibits prostacyclin in the CNS.
    4. Analgesic effects
    5. Anti-inflammatory effects
    1. Aspirin
    2. Acetaminophen
    3. Vitamin C
    4. Zinc
    5. acupuncture

    Author of lecture Acetylsalicylic Acid (ASA)

     Pravin Shukle, MD

    Pravin Shukle, MD

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    This presentation is very interesting and very good structured
    By Roxy M. on 01. December 2016 for Acetylsalicylic Acid (ASA)

    This presentation is very interesting and very good structured. Congrats.