00:01 In von Willebrand disease our focus is going to be on, once again, how much of my von Willebrand factor I have present? The combination of platelet function and also what clotting factor? Which one? VIII. 00:16 The combination of the two is going to give you what test? Good. 00:21 An increase in bleeding time and an increase in PTT. 00:25 And here we go. 00:26 The types. 00:27 We have type I, mild decrease in von Willebrand factor. 00:31 Mild. 00:33 Type II , a defect in von Willebrand factor function but more commonly is the one you?re gonna be looking for with complete absense of complete von Willebrand factor. 00:45 And not only that but you also have lack of stabilization of factor VIII activity. 00:52 Signs and symptoms include bruising. 00:56 Remember we talked about that lady who may have inserted a tampon, had a pad on, woke up in the morning and still during her menses are soaking the sheets with blood. 01:07 Lots of blood everywhere. 01:09 Bleeding, especially mucous membrane?menorrhagia, unfortunately. 01:12 At the same time you can also expect there to be iron deficiency, right? Obviously, lots of bleeding taking place. 01:18 Laboratory test include the following. 01:21 Predict what?s gonna happen first, please? Increase in PTT and increase in bleeding time and especially for type III, abnormal ristocetin cofactor assay. 01:32 In other words, the ristocetin is then going to cause what?s known as aggregation and decreased von Willebrand factor and factor VIII. 01:42 While here you?re looking at and focusing on type I and type III. 01:47 Ultimately, if you?ve been following me, you come to this table and everything should speak to you. 01:54 Laboratory testing for bleeding diathesis. 01:57 I wanna point out what?s important for each one. 01:59 Pay attention. 02:01 Aspirin increase in bleeding time, lack of thromboxane, no aggregation, platelet count perfectly normal, no petechia. 02:11 Thrombocytopenia whatever the cause may be, obviously, decrease in platelet count, increase in bleeding time only. 02:20 Von Willebrand disease either class or type I and type III. 02:24 You?d expect there to be an increase in bleeding time because the von Willebrand factor is not functioning properly, a bind to glycoprotein Ib and PTT is elevated due to lack of stabilization of factor VIII. 02:37 Hemophilia A, let's talk about severe. 02:40 Not much activity going on with your factor VIII so therefore resulting in increase in PTT. 02:49 DIC everything?s elevated except for platelet count and that?ll be decreased. 02:56 Warfarin and heparin, well you tell me. 02:59 Warfarin which test are you gonna use? Remember WEPT? Warfarin Extrinsic PT. 03:06 If it?s not warfarin, it?s heparin. 03:08 If it?s not extrinsic, it?s intrinsic. 03:11 If it?s not PT, PTT. 03:13 Welcome to heparin.
The lecture von Willebrand's Disease (vWD) by Carlo Raj, MD is from the course Hemodynamics.
Type 3 Von Willi brand factor disease shows which of the following features?
Defective Von Willi brand factor is a feature of which of the following?
Which of the following laboratory investigation will have elevated results in Von Willi brand factor disease?
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