Vitamin D (Calciferol, Calcitriol)

by Georgina Cornwall, PhD

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    00:00 Then we move on to our final fat soluble vitamin.

    00:05 Vitamin D, calciferol or calcitriol.

    00:10 Vitamin D has a number of different forms.

    00:13 The vitamin that we take as a supplement will generally be in the D3 form.

    00:19 And it is involved in metabolic pathways that involve increase in calcium absorption and stimulating osteoblasts.

    00:29 So that they deposit calcium into the bones.

    00:33 So here we can see the pathway that the biggest key here I can say is, it relies on the sun to take a cholesterol and turn it into vitamin D3.

    00:45 So the sun is ultimately our best source of vitamin D3.

    00:50 You can see that's along the way there are various conversions to make D3 into it's active form that we can use which is the calcitriol.

    01:00 And that is use in all the different processes that we have discussed.

    01:05 Also I want to bring to light and as it's with the sun, the same cholesterol molecule in D3 pathway leads to the manufacture of many of our steroid hormones.

    01:17 So stay in the sun.

    01:20 So what's sorts of things can lead to a vitamin D deficiency.

    01:25 Well, the first one that we may not jump to the conclusion of is breast milk and no sunshine.

    01:32 Because unlike cows milk which we fortify, breast milk does not actually contain adequate vitamin D on it's own.

    01:41 And so sun exposure is critical.

    01:44 So make sure that your patient's children get plenty of sun along with the breast milk.

    01:51 And the next thing that we can see from a deficiency is either in children or in adults.

    01:58 Rickets is a symptom we don't see it much in the United States.

    02:02 But results from a vitamin D deficiency.

    02:05 Because we see less calcification of the bones.

    02:08 On occasion we'll see that demineralization or loss of minerals from the bones in adults.

    02:16 In which case we call it osteomalacia.

    02:18 In the case of osteomalacia, it can result from vitamin D deficiency obviously.

    02:26 But I've read some articles recently, about how a drug addiction and alcoholism can actually impact the absorption of vitamin D unless mineralization of the bones.

    02:39 And literally the bones will become quite bendy.

    02:41 And we can also see this deficiency evident in older adults.

    02:48 Because if there's less vitamin D then there is less minerlization.

    02:54 And thus we have much more likelihood of damage to the bones and fractures and such.

    03:00 So on that note, here's a quick summary of all of our fat soluble vitamins.

    03:08 Recall that visual and take a moment before you move on to another lecture to write down everything that you remember about the naked fat soluble vitamins.

    03:21 And I look forward to seeing you in the next lecture.

    About the Lecture

    The lecture Vitamin D (Calciferol, Calcitriol) by Georgina Cornwall, PhD is from the course Nutrition. It contains the following chapters:

    • Vitamin D - Calciferol, Calcitriol
    • Summary: Fat Soluble Vitamins

    Included Quiz Questions

    1. D
    2. C
    3. E
    4. A
    5. B
    1. Rickets
    2. Osteomalacia
    3. Osteomyelitis
    4. Osteogenesis imperfect
    5. Renal osteodystrophy

    Author of lecture Vitamin D (Calciferol, Calcitriol)

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD

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