00:00 Then we move on to our final fat soluble vitamin. 00:05 Vitamin D, calciferol or calcitriol. 00:10 Vitamin D has a number of different forms. 00:13 The vitamin that we take as a supplement will generally be in the D3 form. 00:19 And it is involved in metabolic pathways that involve increase in calcium absorption and stimulating osteoblasts. 00:29 So that they deposit calcium into the bones. 00:33 So here we can see the pathway that the biggest key here I can say is, it relies on the sun to take a cholesterol and turn it into vitamin D3. 00:45 So the sun is ultimately our best source of vitamin D3. 00:50 You can see that's along the way there are various conversions to make D3 into it's active form that we can use which is the calcitriol. 01:00 And that is use in all the different processes that we have discussed. 01:05 Also I want to bring to light and as it's with the sun, the same cholesterol molecule in D3 pathway leads to the manufacture of many of our steroid hormones. 01:17 So stay in the sun. 01:20 So what's sorts of things can lead to a vitamin D deficiency. 01:25 Well, the first one that we may not jump to the conclusion of is breast milk and no sunshine. 01:32 Because unlike cows milk which we fortify, breast milk does not actually contain adequate vitamin D on it's own. 01:41 And so sun exposure is critical. 01:44 So make sure that your patient's children get plenty of sun along with the breast milk. 01:51 And the next thing that we can see from a deficiency is either in children or in adults. 01:58 Rickets is a symptom we don't see it much in the United States. 02:02 But results from a vitamin D deficiency. 02:05 Because we see less calcification of the bones. 02:08 On occasion we'll see that demineralization or loss of minerals from the bones in adults. 02:16 In which case we call it osteomalacia. 02:18 In the case of osteomalacia, it can result from vitamin D deficiency obviously. 02:26 But I've read some articles recently, about how a drug addiction and alcoholism can actually impact the absorption of vitamin D unless mineralization of the bones. 02:39 And literally the bones will become quite bendy. 02:41 And we can also see this deficiency evident in older adults. 02:48 Because if there's less vitamin D then there is less minerlization. 02:54 And thus we have much more likelihood of damage to the bones and fractures and such. 03:00 So on that note, here's a quick summary of all of our fat soluble vitamins. 03:08 Recall that visual and take a moment before you move on to another lecture to write down everything that you remember about the naked fat soluble vitamins. 03:21 And I look forward to seeing you in the next lecture.
The lecture Vitamin D (Calciferol, Calcitriol) by Georgina Cornwall, PhD is from the course Nutrition. It contains the following chapters:
Which vitamin can become deficient in infants who are exclusively breastfed?
A young boy comes to you with the complaint of frontal bossing and bowed legs. He also has kyphoscoliosis and hypocalcemia. Which is the most likely diagnosis?
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