Vitamin B9 (Folic Acid)

by Georgina Cornwall, PhD

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    So here in our second lecture on water soluble vitamins, we'll be addressing B9 and B12 which are pretty tightly tied together as well as vitamin C. Which is a little bit more simple after we get through these. So B9 is folic acid or folate. And B9 is primarily involved or it's biggest feature is that, it's involved in nucleotide production. So anytime we need more DNA, we need to have a lot of folate. That's also involved in methylation of DNA. So again, anytime we have extra cell division going on, we need additional folate. So, imagine sometimes if you can where we might see extra cell division going on. Of course we know that we have uncontrolled cell division in cancer. And everytime there is a cell division each new cell needs a new copy of DNA. And thus the demand for nucleotides goes up. Pregnancy of course is a time where we have increase cell divsion. So it's very important for a pregnant patient to make sure they are taking in enough folic acid. During infancy a child is going under loads of cell divisions to grow. And finally hemolytic anemias like sickle cell anemia. We definitely need to have more DNA because these bloods cells are being destroyed. And we have an increased rate of cell division in the blood cells. And they need their own DNA. And so folate demands go up. So anytime we have exta cell division, we may have a deficiency in folic acid. And that will present itself as megaloblastic anemia. Now what happens in megaloblastic anemia. Mega is sort of the key there. With megaloblastic anemia we see that there is a decreased red blood cell count or decreased hematocrit, right. And this is because cells are not making...

    About the Lecture

    The lecture Vitamin B9 (Folic Acid) by Georgina Cornwall, PhD is from the course Nutrition. It contains the following chapters:

    • Vitamin B9 - Folate (Folic Acid)
    • Folate Metabolism

    Author of lecture Vitamin B9 (Folic Acid)

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD

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