Vitamin B12 (Cobalamin)

by Georgina Cornwall, PhD

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    So now let's move on to B12 or cobalamin. As you can imagine B12 has some similar manifestations or deficiency of as we see in B6. But B12 is the one that is stored in liver. Primarily we also see B9 as a I mentioned before. But B12 has a years worth of storage actually in the liver. So B12 deficiency is only something we really have to consider when people are not consuming animal proteins because B12 is found in animal products. Specifically liver is a great source of B12. Because as we store it there, other animals store it there too. So B12 is involved in a number of things including nerve cell function and red blood cell production. I bet that's no mystery to you. And fatty acid oxidation. So B12 deficiencies actually have manifestations beyond that of B9 deficiencies. So wanted to remind you about fatty acid oxidation. Here you can see an image from our molecular and cell biology lectures talking about fatty acid oxidation. You can see these multicarbon units being chopped up into two carbon sub units attached to acetyl CoA. And then those can enter Krebs cycle and be metabolized. Now we'll address an issue with the metabolism of fatty acids. We know that they get chopped off in pairs. But what happens when we don't have pairs. What if it's an odd number chain. So that is where is we'll see B12 coming into, cause some issues or shortage in it. Coming into cause some issues. Before we go there to the pathway piece, let's look at cobalamin absorption. Because it needs to have digestive enzymes to break down the proteins necessary to remove the B12, right. That makes sense. So in the case of B12, we definitely need stomach acid...

    About the Lecture

    The lecture Vitamin B12 (Cobalamin) by Georgina Cornwall, PhD is from the course Nutrition. It contains the following chapters:

    • Vitamin B12 - Cobalamin
    • B12 - Cobalamin Deficiency

    Author of lecture Vitamin B12 (Cobalamin)

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD

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