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Vitamin D Deficiency: Vitamin D Production and Effects

by Carlo Raj, MD
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    00:01 Let’s take a look at Vitamin D pathologies.

    00:05 Begin by discussion of Vitamin D by looking at the different ways in which Vitamin D is provided to us in the active form.

    00:14 Vitamin D can be taken up by food; Vitamin D can come from the skin with the help of UV light.

    00:24 Rarely can Vitamin D deficiency take place in developed countries through dietary deficiency, but it could very much occur with lack of exposure to the sun.

    00:37 This then gets into circulation, but this would be the inactive form.

    00:41 The first place that it goes to would be to the liver and at the site of liver, it gets 25-hydroxylated.

    00:49 This is the major circulating type of Vitamin D, 25-hydroxylated Vitamin D will then turn down to the kidney.

    00:58 Here, with the help of 1-alpha-hydroxylase, because of PTH working upon it will stimulate the 1-alpha-hydroxylase resulting in the active compound of calcitriol or 1,25 dihydroxycholecalciferol.

    01:11 The actions of this on the intestine… remember that Vitamin D is lipid soluble… the lipid soluble vitamins are ADEK… A, D, E, K.

    01:24 The D, Vitamin D, will pass through the membrane, act upon the nucleus and so, therefore, bring about transcription/translation where you can then reabsorb your calcium from the intestine and Vitamin D works upon the kidney to reabsorb both calcium and phosphate whereas PTH only reabsorbs calcium.

    01:47 Production effects of Vitamin D 1,25 dihydroxycholecalciferol reabsorbs your calcium.

    01:54 Unlike PTH, Vitamin D does not promote renal phosphate wasting.

    01:58 In fact, it promotes reabsorption.


    About the Lecture

    The lecture Vitamin D Deficiency: Vitamin D Production and Effects by Carlo Raj, MD is from the course Parathyroid Gland Disorders.


    Included Quiz Questions

    1. 1α-hydroxylase, hydroxylation
    2. UDP-glucoronyltransferase, glucoronidation
    3. Glycosyltransferase, glycosylation
    4. 1α-hydroxylase, glycosylation
    5. Oxidoreductase, oxidation
    1. 25 OH D3
    2. 7-OH-calciferol
    3. 1, 25 (OH)2 D3
    4. 25, 25 OH D3
    5. Vitamin D2

    Author of lecture Vitamin D Deficiency: Vitamin D Production and Effects

     Carlo Raj, MD

    Carlo Raj, MD


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