Vitamin D Deficiency: Vitamin D Production and Effects

by Carlo Raj, MD

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    Let’s take a look at Vitamin D pathologies. Begin by discussion of Vitamin D by looking at the different ways in which Vitamin D is provided to us in the active form. Vitamin D can be taken up by food; Vitamin D can come from the skin with the help of UV light. Rarely can Vitamin D deficiency take place in developed countries through dietary deficiency, but it could very much occur with lack of exposure to the sun. This then gets into circulation, but this would be the inactive form. The first place that it goes to would be to the liver and at the site of liver, it gets 25-hydroxylated. This is the major circulating type of Vitamin D, 25-hydroxylated Vitamin D will then turn down to the kidney. Here, with the help of 1-alpha-hydroxylase, because of PTH working upon it will stimulate the 1-alpha-hydroxylase resulting in the active compound of calcitriol or 1,25 dihydroxycholecalciferol. The actions of this on the intestine… remember that Vitamin D is lipid soluble… the lipid soluble vitamins are ADEK… A, D, E, K. The D, Vitamin D, will pass through the membrane, act upon the nucleus and so, therefore, bring about transcription/translation where you can then reabsorb your calcium from the intestine and Vitamin D works upon the kidney to reabsorb both calcium and phosphate whereas PTH only reabsorbs calcium. Production effects of Vitamin D 1,25 dihydroxycholecalciferol reabsorbs your calcium. Unlike PTH, Vitamin D does not promote renal phosphate wasting. In fact, it promotes reabsorption....

    About the Lecture

    The lecture Vitamin D Deficiency: Vitamin D Production and Effects by Carlo Raj, MD is from the course Parathyroid Gland Disorders.

    Included Quiz Questions

    1. 1α-hydroxylase, hydroxylation
    2. UDP-glucoronyltransferase, glucoronidation
    3. Glycosyltransferase, glycosylation
    4. 1α-hydroxylase, glycosylation
    5. Oxidoreductase, oxidation
    1. 25 OH D3
    2. 7-OH-calciferol
    3. 1, 25 (OH)2 D3
    4. 25, 25 OH D3
    5. Vitamin D2

    Author of lecture Vitamin D Deficiency: Vitamin D Production and Effects

     Carlo Raj, MD

    Carlo Raj, MD

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