Tumor Suppressor Genes: VHL, WT, NF, BRCA, DCC – Carcinogenesis

by Carlo Raj, MD

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    These tables are huge upcoming. I will give you stories for each one of this. My topic is tumor suppressor gene. You thought perhaps that p53 and Rb was sufficient. I know you did'nt think that. But those are good examples to kick start our discussion of tumor suppressor gene. So what if you had a mutation in which you lose your tumor suppressor. Obviously now can we say that you are going to develop cancer. Okay. Now, let's take a look at other important tumor suppressor genes that you will be responsible for and what kind of cancer does it develop. Von Hippel-Lindau disease. Normally, this is a tumor suppressor gene. Normally, Von Hippel-Lindau which we will talk about later further controls what's known as hypoxic inducible factor 1-alpha. HIF-1-alpha. That is a factor that controls, VEGF. Am I giving you too much detail. Have you met me. Everything that I tell you is imperative to know for your boards. So you can get your 250, 260, 270. There is no ceiling as far as what you can score. Just every once in a while take a deep breath and come back. Von Hippel-Lindau controls your hypoxic inducible factor 1-alpha. This controls VEGF. That controls angiogenesis. Go back to the basics. Cancer, neoplasia, increased proliferation. How much angiogenesis do you require? Forever. You want as much angiogenesis as possible. So that you can do what? Supply blood to your cells, the cancer cells, so they can breath just like you and I. What's the name of that factor? VEGF. Vascular endothelial growth factor. So if VHL has been lost, you are going to have increased VEGF activity and the type of cancer that you definitely want to know it's association with is renal cell carcinoma. We'll talk further if...

    About the Lecture

    The lecture Tumor Suppressor Genes: VHL, WT, NF, BRCA, DCC – Carcinogenesis by Carlo Raj, MD is from the course Cellular Pathology: Basic Principles.

    Included Quiz Questions

    1. Von-Hippel Lindau disease
    2. Wilms' tumor
    3. Colon cancer
    4. FAP
    5. Breast cancer
    1. WT-1
    2. WT-2
    3. VHL
    4. DCC
    5. NF-1
    1. Neurofibromatosis type II- NF-2- acoustic neuromas
    2. Neurofibromatosis type I- NF-1- schwannomas
    3. Neurofibromatosis type I- NF-1- meningiomas
    4. Neurofibromatosis type II- NF-1- neurofibromas
    5. Neurofibromatosis type II- NF-2- neurofibromas
    1. BRCA-1
    2. BRCA-2
    3. DCC
    4. VHL
    5. NF-2

    Author of lecture Tumor Suppressor Genes: VHL, WT, NF, BRCA, DCC – Carcinogenesis

     Carlo Raj, MD

    Carlo Raj, MD

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