Usage of Physical Maps – Gene Mapping

00:00 it certainly not very easy to use genetic mapping techniques on human genome. However, because we have a sequence now we can use physical maps.

00:05 And you will learn a lot more about physical maps in the lectures on genomics, very cool stuff going on there. But some other things that we might use in estimating distances and putting physical maps and genetic maps together are anonymous markers. We are going to introduce some of those anonymous markers when we get into biotechnology and genomics, but these are markers that we have identified on chromosomes and that can be visualized using molecular techniques, things that weren’t available back in Thomas Hunt Morgan's time.

00:41 Another thing that we will visit are single nucleotide polymorphisms, that is at one nucleotide, there is a base change and this is an example of one of those sorts of markers where we can see that there is a base change at one nucleotide and we can connect that to a certain gene and estimate positions within the genome. In fact, now we can estimate with very specific granularity precise locations of genes on the genome, but again that is for the chapter on genomics. Just want to introduce some of the ways that we can address mapping in human genomes. Recall that genetic mapping is relative distances based on recombination frequency and we will go into physical mapping real distances later on.

01:34 At this point, you should be able to describe the nature of linkage groups and differentiate between linked and unlinked genes as well as calculate mapped distance based on frequency of recombinations. Thank you so much for watching. I look forward to seeing you again soon.