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Upregulation and Downregulation – Pharmacodynamics

by Pravin Shukle, MD
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    Let's talk about something called up and downregulations. This is a process where the number of receptors is dependant upon receptor binding. So at the top of our image here, you can see that upregulation refers to a system where you have more and more receptors being expressed at the cell surface because there is very little activity. So, the net result is, is that if you have low concentration of a drug, your cell becomes more sensitive to that drug because it has more receptors. Downregulation or tachyphylaxis is where you have the opposite. You have fewer and fewer receptors because they are always being used up and broken down. That's called downregulation and the effect on the drug is tachyphylaxis, which is a reduced drug effect over time....

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    The lecture Upregulation and Downregulation – Pharmacodynamics by Pravin Shukle, MD is from the course Pharmacokinetics and Pharmacodynamics.


    Author of lecture Upregulation and Downregulation – Pharmacodynamics

     Pravin Shukle, MD

    Pravin Shukle, MD


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