00:01
Now, we have a unique category of delivery vehicles called unstable phase mixtures.
00:07
So these are what we call biphasic liquids. So you can see an example here of a biphasic liquid.
00:12
If you look carefully on this bottle, there's actually two phases on the bottle.
00:17
On the bottom, there's a water phase and on the top, there's an oil phase.
00:22
Now you have to mix them into this kind of milky substance for it to be activated.
00:28
Now, why in the world would you have something like this?
Well, if you have a drug for example that will interact with the emulsifier,
you wanna keep them separate until the last possible moment.
00:43
Now, it's mostly used in so-called natural product
where the marketing strategy is to minimize ingredients with long names.
00:51
So I already told you that emulsifiers maintain a stable mixture of two products
that are normally non-mixable or immiscible.
00:59
So if you wanna avoid using the emulsifier which has a long name
and scares people without education, then you can use a biphasic liquid.
01:09
Emulsifiers that we commonly use so that we don't have to use a biphasic liquid include these different products.
01:17
All of these products are safe.
01:20
We also have unstable phase mixtures with biphasic suspensions.
01:28
So a suspension is a component that has a solid component, usually a powder.
01:34
And then the continuous phase which is some kind of a liquid.
01:38
The important aspect of this though is that the powdered substance is so heavy
that there is absolutely no way that they would maintain their stability.
01:49
Here is an example of a cosmetic product that actually uses it's -- they call it mud.
01:55
But really, it's crushed up rock that is suspended in an oil phase.
01:59
These are -- this one here is a cosmetic with a clay particle.
02:03
I can't really discern why people would use this product but it's actually fairly commonly used.
02:10
We also have tints, T-I-N-T-S, tints. These are often using metals and stone to give it color.
02:18
So an example of this are color rising topical paints.
02:24
Now, we don't think of this as a medication
but remember, patients are going to be applying these colorizing paints
to their skin during costumes and parades and things like that.
02:36
And these can have toxic consequences.
02:38
So we as physicians need to know how they're made, why they're made,
what they're doing with them and what the different components are.
02:45
There's other things that we also look at called supersaturated solutions.
02:50
And a really good example of that is supersaturated solution of potassium iodide.
02:55
Potassium iodide is a compound with a relatively high molar mass.
02:59
We sometimes use supersaturated solutions of potassium iodide
for the treatment of certain disease conditions like erytheme nodosum.
03:07
These are very hard to make. They often end up precipitating out.
03:12
But if you have a particularly skilled pharmacist,
they'll be able to maintain the saturated or supersaturated phase in a continuous stable medium.
03:22
Okay, that's it. I told you it would be quick, but it will be useful when you get out into practice.