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Tumor Suppressor Genes: Definition and Inactivation – Carcinogenesis

by Carlo Raj, MD
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    About the Lecture

    The lecture Tumor Suppressor Genes: Definition and Inactivation – Carcinogenesis by Carlo Raj, MD is from the course Cellular Pathology: Basic Principles.


    Included Quiz Questions

    1. p53
    2. Rb
    3. E2F
    4. Cyclin D
    5. MDM2
    1. Second hit: inherited germline mutation
    2. Both gene copies must be inactivated
    3. First hit: inherited germline mutation
    4. First hit: inherited somatic mutation
    5. Second hit: acquired somatic mutation
    1. Germline mutation of Rb on chromosome 13
    2. Germline mutation of p53 on chromosome 17
    3. Sporadic mutation of Rb on chromosome 13
    4. Germline mutation of p53 on chromosome 13
    5. Germline mutation of Rb on chromosome 17
    1. Lymphocytic retinal tumor
    2. Weight loss
    3. Mediastinal nodule
    4. Infertility
    5. Multiple primary cancers

    Author of lecture Tumor Suppressor Genes: Definition and Inactivation – Carcinogenesis

     Carlo Raj, MD

    Carlo Raj, MD


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