00:00
Moving on to sputum
production: This is evidence
of active inflammation of the lower airways
in general. Clearly, viral infections and
respiratory tract infections often lead to
a bit of sputum production, but again, that's
a short-lived problem that will last for a
few days, then go away. Chronic sputum production
is quite unusual, and that suggests either
the patient is a smoker with some degree of
chronic bronchitis, or has smoking-related
lung diseases such as COPD, or has bronchiectasis.
00:30
And occasionally, patients with asthma will
produce some phlegm as well. And interstitial
lung disease: Although that normally causes
breathlessness, it can cause cough, and that
cough can be productive of some phlegm.
There are several different descriptions of
phlegm, but essentially, you either describe
the phlegm as mucoid, which is clear, white
phlegm—and that doesn't normally suggest
they have a bacterial infection—or it's
purulent, in which case the phlegm is green,
it's thick, and it's tenacious. And that is
likely to be due to an active bacterial infection.
And there's something which is in between,
mucopurulent, where it's slightly purulent
but with a mixture of mucoid as well. Patients
with asthma do often describe coughing up
yellow phlegm, and that's due to eosinophils,
probably, present in the sputum that's being
produced. Hemoptysis is when you cough up
blood, and I'll describe that in a little
bit more detail shortly.
01:26
So sputum production occurs when people have
exacerbations of chronic lung disease due
to the underlying infection. So patients with
COPD often cough up a little bit of gray–white
phlegm most days due to their chronic bronchitis,
but when they get an infective exacerbation,
that phlegm becomes green, thick, and larger
in quantity, suggesting an active bacterial
problem. In bronchiectasis, the hallmark of
bronchiectasis would be daily production chronically
(i.e. every day) of purulent phlegm, so green
or discolored, thick phlegm being produced
each day. And with patients with severe disease,
this can be produced in very high quantities.
02:04
A cup a day is not uncommon in patients with
very severe bronchiectasis. Patients with
less severe bronchiectasis may not cough up
purulent phlegm each day; it might be relatively
clear and only become purulent during exacerbations.
Hemoptysis is blood in the sputum, and minor
hemoptysis—a little bit of blood in the
sputum—is relatively common. New minor hemoptysis
in a smoker: You need to think about lung
cancer. So this is a sign that could indicate
that they have a lung cancer. In most cases,
it does not, but in a smoker coughing up blood
for the first time, you must investigate to
make sure they don't have lung cancer. In
fact, chronic mild hemoptysis—a little bit
of blood being produced every now and then
over months or years—is not uncommon in
some respiratory diseases such as bronchiectasis,
but it is not of any real consequence. It
has no physiological consequence for the patient
and is just a reflection of the underlying
lung disease.
03:06
The situations which might suggest an important
cause of hemoptysis is if it's pure, fresh
blood rather than just a few flecks or a few
streaks mixed in with phlegm. If the patient
actually hasn't got an abs… actually hasn't
got an active infection at the time, that
would make me more worried about the cause
of the blood. And clearly, a short history,
as we already mentioned, would concern you.
If they've had a long history of minor hemoptysis,
that's not a major problem. Somebody who'd
never had hemoptysis, is now coughing up blood
every few days: I would be concerned as to
why that may be happening. Acutely, if you
cough up blood associated with pleuritic chest
pain, that would suggest they have an infection
or pulmonary embolism as an active problem.
But that should be detectable by other symptoms
and signs as well.
Major hemoptysis is quite different to minor
hemoptysis in that it is actually a serious
problem. It can be life-threatening, and the
patient should be admitted to hospital and
investigated urgently to identify what's happening.
04:12
A major hemoptysis is defined as 100 to 200
ml (half to a full cup) of fresh blood produced
in one day. That sort of rate of blood production
puts you at risk of either drowning in your
own blood production down the bronchial tree
or significant volume loss of circulating
blood.
So the list of causes of minor hemoptysis
is very large, but the common causes will
be chronic bronchitis: Patients with a bit
of COPD are coughing a lot and they get a
little bit of blood in their phlegm as a consequence
of having burst a small blood vessel. But
there's a situation there that they could
have lung cancer, so you do need to take that
very seriously and investigate if somebody
presents with new hemoptysis. Bronchiectasis
is a very common cause of hemoptysis. And
then acute lung infections (pneumonia, bronchitis)
may cause hemoptysis. Tuberculosis in high-risk
countries and high-risk populations must be
considered in somebody presenting, especially
if it's quite frank hemoptysis. And pulmonary
emboli we've already discussed.
05:17
An important point is that many people presenting
with minor hemoptysis, we don't really know
why it happens. It's called cryptogenic hemoptysis.
That's about 40% of cases. And there's a range
of other causes. Pulmonary edema classically
causes a frothy pink phlegm due to a mixture
of white phlegm with just a low amount of
blood in it, making it pink in color. And
then you need to think about mycetomas: fungal
balls which are colonizing cavities in the
lung which have been created by previous tuberculosis,
for example, etc., etc.
05:49
Major hemoptysis: There's a relatively limited
number of causes which will cause a massive
blood loss:
1. Lung cancer
2. Bronchiectasis
3. Mycetomas (the fungal walls in preexisting
cavities)
4. Tuberculosis
And then occasionally, that you can get lung
abscesses, severe fungal infections. And there's
arteriovenous malformations, an occasional
fistula between circulating arteries in the
bronchial tree, which can rarely cause major
hemoptysis. But the major problems are cancer,
bronchiectasis, tuberculosis, and mycetomas
that you need to consider in somebody presenting
with a lot of fresh blood being produced.
We've discussed respiratory symptoms, but
actually, one area of very great importance
when taking a history is to work out whether
the patient has systemic symptoms. Now, these
are symptoms suggestive of a systemic problem
of inflammatory or neoplastic nature, and
they're very simple. Does the patient feel
unwell? Have they lost their appetite? Are
they losing weight? Do they feel very fatigued?
And that's different to being breathless.
So patients with COPD will say, "I feel fine
when I'm sitting down, but as soon as I try
and walk 200 yards, I get breathless." That's
quite different from feeling ill and fatigued
if somebody has a cancer, for example.
07:13
And weight loss clearly is a very important
sign. Patients don't normally lose weight
without active dieting—and even with active
dieting—unless they've got a severe underlying
physiological problem such as an infection
or a cancer. And fevers and night sweats,
again, would reflect active inflammatory problem.
So this is important. You need to identify
the patients with systemic symptoms, because
that certainly puts them in a category of
patients who may have problems such as lung
cancer, active infection such as tuberculosis,
and some of the more rare inflammatory causes
of lung disease as opposed to the less systematic…
less inflammatory problems, such as COPD or
asthma.
08:00
So acutely, the main causes of systemic upset
would be pneumonia, but they could also have
other infections such as empyema. And inflammatory
diseases such as hypersensitivity pneumonitis
is also potentially possible. And chronically,
it’s a lung cancer, other malignancies,
tuberculosis, connective tissue diseases that
you need to think about.
08:20
There are other symptoms which are not related
directly to the respiratory tract which are
relevant for respiratory disease. These are
relatively limited number, but the important
ones are bilateral ankle edema. So ankle edema
equals somebody who's got some problem with
their cardiac function in general. And that
could be right heart failure—cor pulmonale—so
that's a consequence of chronic lung disease.
Or it could be pulmonary hypertension independent
of chronic lung disease. So you need to consider
bilateral ankle edema as a respiratory symptom.
08:50
Clearly, it could also reflect congestive
cardiac failure, which is a differential diagnosis
for patients presenting with breathlessness.
Unilateral leg swelling suggests there may
be a deep vein thrombosis: a clot in one of
the veins in that… in the swollen leg which
is indicating that the patient might be presenting
due to P... with respiratory problems because
of pulmonary embolus. So unilateral leg swelling
indicates somebody who might have a DVT and
therefore could have a PE. Hay fever and eczema,
in combination, identify somebody who has
atopy, which is a general allergic sensibility
and means they quite likely, or more commonly,
will have asthma than the nonatopic individual.
We've already discussed that upper respiratory
tract symptoms is a cause of chronic cough
in some people due to a postnasal drip. But
upper respiratory tract symptoms also are
closely associated with some patients with
asthma and bronchiectasis, due to some causes
of bronchiectasis. For example, idiopathic
bronchiectasis frequently have upper respiratory
tract infection as does cystic fibrosis and
primary ciliary dyskinesia. Bone pain, neurological
symptoms, other symptoms might suggest that
the patient… of new onset can occur in patients
who've got lung cancer metastases outside
the respiratory system and are relevant in
those circumstances where you think that cancer
might be the diagnosis.