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Sympathoadrenal System and Catecholamine – Adrenal Medulla

by Carlo Raj, MD
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    Adrenal gland pathology, we will dive into the medulla and the important clinical significance and many of those associations that we will see with it, do not underestimate what we have to say about the adrenal medulla. First and foremost, understand this is often referred to as being the sympathoadrenal system. Why? Because when we have a fight or flight response, sympathetic response from the adrenal medulla wherein the biochemical pathway of forming epi, epinephrine; at the very end on your right is epinephrine. You have an enzyme here that you want to be familiar with known as phenylethanolamine-N-methyltransferase, PNMT, the abbreviation that you’ll be oh so comfortable with and familiar when you’re actually forming epi, epi, epi. For example, when there is pheochromocytoma, obviously it’s going to be one of the discussions there will be increased activity of this very enzyme. It would be nice if you would be able to identify it. In the meantime, you have some other enzymes here that you should be familiar with from CNS pharmacology. All of these coming from tyrosine, tyrosine hydroxylase, DOPA decarboxylase, Dopamine-beta-hydroxylase… all those enzymes are incredibly important as you know in different parts of your pharmacologic discussions. With your epinephrine, it works on every single adrenergic receptor known to man and the pneumonic that’s quite cute that you may want to use is called BLOW. What does that even mean? At low doses of epinephrine, it works on beta receptors; at higher doses ,we then work on our alpha receptors therefore then works like your norepinephrine. Alpha 2 receptors obviously was going to inhibit centrally the release of your norepinephrine, if you remember [Inaudible 00:01:54] and such, beta-1 receptors and beta-2 receptors at low doses of epinephrine will in fact work on these. In the meantime, what you...

    About the Lecture

    The lecture Sympathoadrenal System and Catecholamine – Adrenal Medulla by Carlo Raj, MD is from the course Adrenal Gland Disorders.


    Included Quiz Questions

    1. Inability to form epinephrine
    2. Inability to form dopamine
    3. Inability to form norepinephrine
    4. Inability to form DOPA
    5. Inability to form tyrosine
    1. Alpha1
    2. Alpha2
    3. Beta1
    4. Beta2
    5. Beta1 and Beta2
    1. Decreased BMR
    2. Bronchodilation
    3. Lipolysis
    4. Increased heart rate
    5. Inhibition of GI secretions

    Author of lecture Sympathoadrenal System and Catecholamine – Adrenal Medulla

     Carlo Raj, MD

    Carlo Raj, MD


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