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Nuclear Hormone Receptors and Steroid Hormone Signaling

by Kevin Ahern, PhD
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    So as I noted earlier, not all signaling systems work through membrane receptors. Some examples of those that work internal to the cell - the steroid hormone receptor which works by the process of a steroid hormone diffusing its way across the membrane ultimately to the receptor in the cytoplasm. The thyroid hormone receptor also works in a fashion as I will describe here through the transport system that gets things into the nucleus. Vitamin D has a little bit different route that it gets there. It gets into the cell not through the receptor but through action of a vitamin D transport protein that grabs the vitamin D and the cell membrane and then transports it to the receptor in the cytoplasm, where that then takes the vitamin D into the nucleus to exert its effects. And at last the retinoic acid/retinoid receptor has a transport system that also gets retinoic acid ultimately into the nucleus for controlling gene expression. Each of these nuclear hormone receptors is depicted schematically here. They have an N-terminal region that’s shown on the left and a C-terminal region that’s shown on the right. And that N-terminal region has a DNA binding domain that is specific to binding a specific sequence within a DNA molecule. Another part of the protein has a ligand binding domain, that’s the part that binds to the receptor hormone. It is the binding of that receptor hormone that causes the overall receptor to exert the control on gene expression that it controls. So these receptor hormones bind to specific sequences in DNA molecules as I said, that are known as hormone response elements that occur in the DNA. And these are specific for each of the individual transcription factors that I’ve described here. Now nuclear hormone signaling helps to...

    About the Lecture

    The lecture Nuclear Hormone Receptors and Steroid Hormone Signaling by Kevin Ahern, PhD is from the course Hormones and Signal Transduction. It contains the following chapters:

    • Nuclear Hormone Receptors
    • Steroid Hormone Signaling
    • Steroid Hormone Signaling

    Included Quiz Questions

    1. None of the answers are true.
    2. All of the answers are true.
    3. They transmit signals through the lipid bilayer.
    4. They are protein kinases.
    5. They act more rapidly than GPCRs.
    1. All of the answers are true.
    2. None of the answers are true.
    3. They cause steroid hormone receptors to release heat shock proteins.
    4. They cause the steroid hormone receptor to carry them to the nucleus.
    5. They stimulate transcriptional activity of their receptors.

    Author of lecture Nuclear Hormone Receptors and Steroid Hormone Signaling

     Kevin Ahern, PhD

    Kevin Ahern, PhD


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