Lectures

Signaling Gone Wild

by Kevin Ahern, PhD
(1)

Questions about the lecture
My Notes
  • Required.
Save Cancel
    Learning Material 2
    • PDF
      Slides HormonesSignalTransduction Biochemistry.pdf
    • PDF
      Download Lecture Overview
    Report mistake
    Transcript
    The last thing I want to talk about in this lecture relates to the process that I call signaling gone wild. And we’ve already seen a little bit of a hint of this already. Signaling proteins play important roles in growth and division as we’ve seen; the epidermal growth factor was a good example. I need to define a term here that I’m going to be using, so that you’re familiar with it. And it’s a term you’ve probably heard before, that term is oncogene. An oncogene is a mutated form of a gene whose activity can cause uncontrolled growth. I’ve described one already, that was the RAS protein. When we mutated the cellular RAS protein so that it could no longer cleave GTP, the RAS protein was left in the on state and the cell was left in a continual process of dividing. That mutated RAS was an oncogene. Well what was it before it mutated? It was a normal gene we call a proto-oncogene. So a proto-oncogene is a gene that has the ability to become an oncogene if it gets mutated. And you start to think, well mutation is one of the ways in which we can make cancer, in fact mutation is the primary way in which we can make cancer. How do we avoid mutation? Well there’s a variety of thoughts about that but one of which is to be careful of the food you eat, the water you drink and the air you breathe, because it’s materials inside of those things that can cause and favor mutation. Now mutations in signaling systems can often lead to tumor formation. They can happen in a variety of ways. One way are those mutations that affect the protein structure or function. Let’s imagine that we had a...

    About the Lecture

    The lecture Signaling Gone Wild by Kevin Ahern, PhD is from the course Hormones and Signal Transduction. It contains the following chapters:

    • Signaling Gone Wild
    • Mutations Affecting Protein Structure/Function

    Included Quiz Questions

    1. They are genes whose structure/function has been disrupted.
    2. They are unmutated genes that form proto-oncogenes.
    3. They play normal roles in cell growth and division.
    4. All of the answers are true.
    5. None of the answers are true.
    1. All of the answers are true.
    2. None of the answers are true.
    3. Its unmutated form helps control cell division.
    4. It can become an oncogene with a single mutation.
    5. It is found mutated in many cancers.
    1. It is a tyrosine protein kinase that is not a receptor.
    2. It is activated by phosphorylation.
    3. It prevents cells from dividing when it has no phosphate.
    4. All of the answers are true.
    5. None of the answers are true.

    Author of lecture Signaling Gone Wild

     Kevin Ahern, PhD

    Kevin Ahern, PhD


    Customer reviews

    (1)
    5,0 of 5 stars
    5 Stars
    5
    4 Stars
    0
    3 Stars
    0
    2 Stars
    0
    1  Star
    0