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Slides 03 ChromosomeTheroy Genetics.pdf
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00:02 Sex determination in humans, you are probably all fairly familiar with the female has a possibility of contributing X and X and the male could contribute and X or a Y. And the Y chromosome is a little bit special. First of all, it is tiny, but it also has a gene on it that is involved in sex determination. It is called the SRY region of the Y chromosomes. 00:28 It is the sex-determining region of the Y chromosome. And if that gene is present and expressed, then we will see maleness, but if that gene is not present maybe there is no Y chromosome or maybe the gene is broken, then by default we will see the female phenotype in human condition. We know how this works out. We have an X and a Y. We can have male progeny or X is in excess, we have female progeny. Fifty percent chance of boys or girls based on this sex determining system.
About the Lecture
The lecture Sex Chromosomes – Chromosome Theory and Sex Linkage by Georgina Cornwall, PhD is from the course Understanding Genetics.
Included Quiz Questions
What does the term wild type mean?
- It refers to the most common phenotype.
- It refers to the dominant phenotype.
- It refers to neither to a sex-linked trait.
- It refers to a recessive phenotype.
Which of the following is NOT true regarding human sex chromosomes?
- The SRY region on the Y chromosome of human male determines the femaleness.
- Human female cells contain XX sex chromosomes in their nucleus, whereas human males have XY sex chromosomes.
- The translocation of SRY region from Y to X chromosome during meiosis leads to XX male syndrome.
- SRY gene is an intronless gene that encodes for a testis-determining factor to initiate male sex determination.
- Mutated SRY gene leads to XY females with Swyer syndrome characterized by gonadal dysgenesis.
Author of lecture Sex Chromosomes – Chromosome Theory and Sex Linkage
Georgina Cornwall, PhD
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