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Lymphadenopathy: Serum Protein Electrophoresis – White Blood Cell Pathology

by Carlo Raj, MD
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    With serum protein electrophoresis, a quick word or two about each one of the other zones so that you’re familiar and you don’t miss questions unnecessarily. I want you to go back and take a look at the normal serum protein electrophoresis and on the electrophoresis, I want you to identify alpha-1 zone, okay? Now, when you say alpha-1 zone, you should automatically think about alpha-1 antitrypsin, okay? That should make your life a little bit easier. Now with alpha-1 antitrypsin, what does this mean? Well, a decreased band is seen in deficiency. It is decreased in nephrotic syndrome. And nephrotic syndrome, you’ll know that you’re losing quite a bit of protein, right? Quite a bit or albumin and perhaps even quite a bit of alpha-1 antitrypsin. So therefore, you expect there to be a decrease in the alpha-1 zone. In addition, if you lose enough, enough, enough of your alpha-1 antitrypsin at some point, well, emphysema, you know about elastase. If you find absolutely no alpha-1, this to you should indicate, “Oh, maybe” or, as far as you’re concerned, should heighten the suspicion of – Does my patient have alpha-1 antitrypsin deficiency? Alpha-1 zone, the number one enzyme that should come to mind is your alpha-1 antitrypsin. We’ve talked about this in greater detail. I’m referring to my gene, PI, protease inhibitor. I want you to go back and take a look at the serum protein electrophoresis. And this time, we have an alpha-2 zone, okay? So little zones that you want to make sure that you have an idea as to what they are. The alpha-2 zone is the – The abbreviation that I’ll be using here is alpha-2 macroglobulin or AMG. And more importantly, for you, in the discussion that we’ve had prior is haptoglobin, okay? When...

    About the Lecture

    The lecture Lymphadenopathy: Serum Protein Electrophoresis – White Blood Cell Pathology by Carlo Raj, MD is from the course Lymphadenopathy – White Blood Cell Pathology (WBC).


    Included Quiz Questions

    1. Nephrotic syndrome
    2. Pregnancy
    3. Appendicitis
    4. Multiple myeloma
    5. Malignant lymphoma
    1. Normal alpha 2 and elevated alpha 1
    2. Elevated alpha 1 and normal gamma
    3. Elevated beta 1 and normal alpha 2
    4. Elevated alpha 1 and alpha 2
    5. Elevated alpha 1 and normal beta 2

    Author of lecture Lymphadenopathy: Serum Protein Electrophoresis – White Blood Cell Pathology

     Carlo Raj, MD

    Carlo Raj, MD


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